Sabri COLAK, Emine Seda GUVENDAG GUVEN, Suleyman GUVEN, Turan ERDOGAN, Yesim BAYOGLU TEKİN, Funda AKPİNAR

TEKRARLAYAN GEBELİK KAYIPLARINDA SCUBE-1 DÜZEYİNİN VE KAROTİS İNTİMA MEDİA KALINLIĞININ DEĞERLENDİRİLMESİ

Amaç: Tekrarlayan gebelik kaybı olan hasta grubu ile tekrarlayan gebelik kaybı öyküsü olmayan hasta grubu arasında serum signal peptid C1r/C1s, Uegf, ve Bmp1 (CUB) epidermal growth factor-like domain-containing protein-1 (SCUBE-1) düzeyinin ve karotis intima media kalınlığının değerlendirilmesi. Materyal ve Metot: Prospektif ve tek merkezli çalışmaya 20-40 yaş arasında 30 tekrarlayan gebelik kaybı öyküsü olan, 30 tekrarlayan gebelik kaybı öyküsü olmayan hasta olgusu alınmıştır. Tekrarlayan gebelik kaybı olanlarda ve kontrol grubunda anatomik, kalıtımsal, endokrin, trombofilik defekti olanlar çalışma kapsamına alınmamıştır. Hasta grubu ile kontrol grubu arasında SCUBE-1 düzeyinde ve ölçülen karotis intima media kalınlığı arasında istatistiksel fark olup olmadığı araştırılmıştır. Bulgular: Demografik özellikler açısından hastalar ve kontrol grupları arasında gravite, parite ve düşükler dışında istatistiksel olarak anlamlı fark bulunmamıştır. TGK kaybı olan hastaların ortalama SCUBE1 düzeyleri (16,44±5,43) kontrol grubunun ortalama SCUBE1 düzeylerinden (10,17±5,19) istatistiksel olarak anlamlı şekilde yüksektir (p=0,001). TGK kaybı olan hastaların ortalama CIMT düzeyleri (0,60±0,09) kontrol grubunun ortalama CIMT düzeylerinden (0,44±0,07) istatistiksel olarak anlamlı şekilde yüksektir (p=0,001). Sonuç: TGK olan grupta yüksek serum SCUBE-1 ve CIMT seviyeleri, iskemi ve endotel disfonksiyonunun TGK etiyolojisinde rol oynayabileceğini düşündürebilir. Gelecekteki çalışmalar TGK'nın tanı, tedavi ve yönetimine ışık tutabilir.

EVALUATION OF SCUBE-1 LEVEL AND CAROTID INTIMA MEDIA THICKNESS IN RECURRENT PREGNANCY LOSS

Objectives: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL).Materials and Methods: This prospective and single-center study included 20-40-year-old 30 patients with and 30 patients without a history of RPL. No patients with any anatomical, hereditary, or endocrinological thrombophilic defects were included. A comparison of SCUBE-1 levels and CIMT were made between the patient and control groups.Results: There were no statistically significant differences between patients and control groups in terms of demographic characteristics except for gravidity, parity, and miscarriages. The mean SCUBE-1 level in the RPL group was statistically significantly higher compared to the control group (16.44±5.43 vs.10.17±5.19, respectively, p=0.001). The mean CIMT value in RPL patients was statistically significantly higher than that of the control group (0.60±0.09 vs.0.44±0.07, respectively, p=0.001).Conclusion: High levels of serum SCUBE-1 and CIMT in RPL may suggest that ischemia and endothelial dysfunction may be involved in the etiology of RPL. Future studies may shed light on the diagnosis, treatment, and management of RPL.

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