İlhami ÜNLÜOĞLU, Uğur BİLGE, Gözde GÜLTEKİN, Muzaffer BİLGİN

Homeostatic Model Assessment Insulin Resistance (HOMA-IR) Değerleri ile Glomerüler Filtrasyon Hızları Arasındaki İlişki: Retrospektif Bir Çalışma

Amaç: Bu çalışmada amacımız insülin direnci seviyesi ile Cockcroft-Gault (CG) ve Chronic Kidney DiseaseEpidemiology Collaboration (CKD-EPI) denklemlerine göre hesaplanan glomerüler filtrasyon hızları (GFH) arasındaki olası ilişkiyi ortaya koymaktır. Materyal Metot: Yaş ortalaması 39,11±10,29 yıl olan 169 kişi (58 erkek, 111 kadın) retrospektif olarak değerlendirildi. Vücut kitle indeksi 30 ve üzeri olanlar obez olarak kabul edildi. Homeostatic model assessment insulin resistance (HOMA-IR) skoru >= 2,7 olanların insülin direnci olduğu kabul edildi. Cockcroft-Gault (CG) ve Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) denklemlerine göre GFH değerleri hesaplandı. Sonuçlar: Kişilerin 94'ü (%55,4) insülin dirençli kabul edildi. İnsülin direnci olan ve olmayan grup arasında yaş ve cinsiyet açısından farklılık yoktu. CG formülüne göre hesaplanan GFH değerleri ve HOMA-IR seviyeleri arasında ilişki vardı. CKD-EPI denklemine göre hesaplanan GFH değerleri ve HOMA-IR seviyeleri arasında ilişki yoktu. CG denklemine göre hesaplanan GFH değerleri insülin dirençli grupta anlamlı olarak daha yüksekti (152,66±48,90 vs 123,12±34,95 ml/min; p

Relationship Between Homeostatic Model Assessment Insulin Resistance(HOMA-IR) Values and Glomerular Filtration Rates (GFR): ARetrospective Study

Objectives: Our aim is to evaluate the possible relationships between insulin resistance levels and glomerular filtration rates (GFR) according to Cockcroft-Gault (CG) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations. Materials and Methods: Data of 169 subjects (58 men, 111 women) with a medium age of 39.11±10.29 years were evaluated retrospectively. The individuals whose body mass index (BMI) value was 30 and over were defined as obese. Homeostatic model assessment insulin resistance (HOMA-IR) scores >= 2.7 were accepted to be insulin resistant. Glomerular filtration rates were calculated by both Cockcroft-Gault and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations. Results: Ninety-four subjects (%55.60) were accepted to be insulin resistant. There was no statistical significance between insulin resistant group and non-resistant group according to age and gender. There was a correlation between HOMA-IR levels and GFR values according to CG equation. There was no correlation between HOMA-IR levels and GFR values according to CKD-EPI equation. According to the GFR values calculated by CG equation, GFR levels were significantly higher in insulin resistant group (152,66±48.90 vs 123.12±34.95 ml/min; p

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