Yusuf DOĞAN, İbrahim KOÇ, Abdülaziz KAYA, Ayşen DÖKME, Eray MANDOLLU, Adem BAYRAKTAR, Zeynel Abidin KARATAŞ

Bronşektazili Hastalarda Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliğinin Değerlendirilmesi

Bu çalışmanın amacı ortalama trombosit hacmi (MPV) ve trombosit dağılım genişliğinin (PDW) bronşektazide belirteç olarak kullanılabilirliğini araştırmaktır. Bildiğimiz kadarıyla çalışmamız MPV ve PDW'nin bronşektazide önemini araştıran ilk çalışmadır. Materyal ve Metot: Kliniğimizce bronşektazi tanısı konan başka kronik bir hastalığı olmayan hastalar ile sigara içen ve içmeyen sağlıklı bireyler çalışmaya dahil edilmiştir. Toplamda 45 bronşektazili, 50 sigara içmeyen ve 50 sigara içen hastanın verileri retrospektif olarak analiz edildi. Bulgular: MPV değerleri incelendiğinde gruplar arasında istatiksel olarak anlamlı farklılık olmadığı görüldü. Trombosit (PLT) değerlerinin ise bronşektazili hastalarda hem sigara içmeyen (p

Assessment of Mean Platelet Volumes and Platelet Distribution Widths In Patients With Bronchiectasis

Aim of this study is to evaluate whether mean platelet volume (MPV) and Platelet Distribution Width (PDW) can be used as markers in bronchiectasis. To the best of our knowledge our study is the first study investigating the importance of MPV and PDW in patients with bronchiectasis. Materials and Methods: Patients in our clinic diagnosed with bronchiectasis but has no other chronic diseases, smoking and nonsmoking healthy subjects included in the study. Totally data of 45 patients with bronchiectasis, 50 nonsmoking healthy subjects and 50 smoking healthy subjects were retrospectively enrolled. Results: MPV levels were insignificant between all groups. Platelets (Plt) were high in patients with bronchiectasis when compared with nonsmokers (p

PDF

___

Goeminne P. and Dupont L. Non-cystic fibrosis bronchiectasis: diagnosis and management in 21.st century. Postgrad Med J 2010; 86(1018):493-501.
Roberts ME, Lowndes L, Milne DE, Wong CA. Socioeconomic deprivation, readmissions, mortality and acute exacerbations of bronchiectasis. Int Med J 2012;42(6):129-36.
Barker A.F. and Bardana E.J. Bronchiectasis: update of an orphan disease. Am Rev Respir Dis 1988; 137(4): 969- 78.
Wang Z. Bronchiectasis: still a problem. Chin Med J (Engl) 2014; 127(1):157-72.
Jordan TS, Spencer EM, Davies P, Tuberculosis, bronchiectasis and chronic airflow obstruction. Respirology 2010; 15(4): 623-8.
Tsang KW. and Tipoe GL. Bronchiectasis: not an orphan disease in the East. Int J Tuberc Lung Dis 2004; 8(6):691- 702.
Boren EJ, Teuber SS, Gershwin ME. A review of non- cystic fibrosis pediatric bronchiectasis. Clin Rev Allergy Immunol 2008; 34(2):260-73.
Keistinen T, Saynajakangas O, Tuuponen T, Kivela SL.Bronchiectasis: an orphan disease with a poorly- understood prognosis. Eur Respir J 1997; 10(12):2784-7.
Coban E and Adanir H. Platelet activation in patients with Familial Mediterranean Fever. Platelets 2008; 19(6): 405- 8.
Arica S, Ozer C, Arica V, Karakuş A, Çelik T,
Gunesacar R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatol Int 2011; 32(11): 3559-63.
Bath PM. and Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7(2):157-61.
Becchi C, Malyan AM, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiol 2006; 72(9):749- 56.
Koç İ, Karataş Z.A, Mandollu E, Mermer A, Kaya A,
Dökme A ve ark. Importance Of Mean Platelet Volume In Patienets With Chronic Obstructive Pulmonary Disease. Gaziantep Med J 2014;20(4):294-8.
Bansal R, Gupta HL, Goel A. Association of Increased Platelet Volume In Patients of Chronic Obstructive Pulmonary Disease: Clinical Implications. JIACM 2002; 40(2):104-7.
Ulasli SS, Ozyurek BA, Yilmaz EB,Ulubay G.Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn 2012; 122(6):284-90.
Erden EŞ, Dokuyucu R, Demirköse M, Yengil E, Sefil F, Bilgiç HK. ve ark. Kronik obstrüktif akciğer hastalığının akut alevlenme ve stabil dönemlerinde ortalama trombosit hacminin incelenmesi. JCEI 2013; 4(4):483-7.
Tuncel T, Uysal P, Hocaoglu AB,Erge DO, Karaman O, Uzuner N.Change of mean platelet volume values in asthmatic children as an inflammatory marker.Allergol Immunopathol (Madr) 2011;40(2):104-7.
Çevik C, Yengil A, Akbay E, Arlı C, Gülmez Mİ, Akoğlu E.Comparison of Mean Platelet Volume Values betweenPatients with Nasal Polyp and Healthy Individuals. Turk Arch Otolaryngol 2013; 51(4):106 -9.
Erden ES, Yengil E, Tuncel E,Bilgiç HK, Demirköse M, Motor S. ve ark..Obstrüktif uyku apne sendromu ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. JCEI 2013; 4(4):492-6.
Barnes PJ. and Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009; 33(5):1165- 85.