LOKAL BİR LEZYONDAN SİSTEMİK TEŞHİSE: KSANTOMLAR VE HİPERKOLESTEROLEMİ
Plastik cerrahi ameliyatlarının büyük bir kısmını cilt lezyonlarının ve cilt altı kitlelerinin çıkartılması oluşturmaktadır. Genellikle tek başına bulunan bu lezyonlar bazen de sistemik bir hastalığın habercisi olabilirler. Kliniğimize vücudunda çok sayıda kitle şikayetiyle başvuran 29 yaş kadın hastada, kitlelerin patoloji sonucunun ksantom ile uyumlu gelmesinin ardından hastada hiperkolesterolemi olabileceği düşünüldü. İleri tetkik ve gerekli konsültasyonlar sonrası hastanın yaşam kalitesini arttıracak uygun lipid düşürücü tedavi başlandı
FROM A LOCAL LESION TO A SYSTEMIC DIAGNOSIS: XANTHOMAS AND HYPERCHOLESTEROLEMIA
The majority of plastic surgery operations is constituted of the excision of skin and subcutaneous masses. In general, these lesions are solitary but sometimes they can be precursors of a systemic disease. A 29-year-old female patient came to our outpatient clinic, complaining of several cutaneous masses on her body. After the excisional surgery, pathology result was consistent with xanthoma. The patient was thought to have hypercholestrolemia. Lipid lowering therapy, that decreases the morbidity of the disease, was iniated according to further laboratory works and appropriate consultations
___
- 1)Parker F. Disorders of metabolism. In: Moschella SL, Hurley JJ; eds. Dermatology. 3rd ed. Vol.2. Philadelphia: WB Saunders Company; 1992.p.1653.
- 2)Brown MS, Goldstein JL. The hyperlipoproteinemia and other disorders of lipid metabolism. In: Harrisons’s Principles of Internal Medicine.12th.ed.Vol.2. New York: McGraw- Hill; 1992.p.1820.
- 3)Civeira F; International Panel on Management of Familial Hypercholestrolemia. Guidelines for the management of heterozygous familial hypercholesterolemia. Atherosclerosis. 2004; 173: 55-68.
- 4)Tsouli SG, Kiortsis DN, Argyropoulou MI, Mikhailidis DP, Elisaf MS. Pathogenesis, detection and treatment of Achilles tendon xanthomas. Eur J Clin Invest. 2005; 35: 236-244.
- 5)Plewing G, Wolff HH, Braun Falco O. Skin disorders caused by disturbances of lipid metabolism. Dermatology. 2002; 37: 849-860.
- 6)Sethuraman G, Thappa DM, Karthikeyan K. Intertriginous xanthomas-A marker of homozygous familial hypercholesterolemia. Indian Pediatr. 2000; 37: 338.
- 7)Saraf SK, Sharma SV. Reconstruction for xanthoma of the achilles tendon. Int Orthop. 1992; 16: 37-38.
- 8)Panman WF, Hamming JJ. Xanthoma of the achilles tendon. Neth J Surg. 1986; 38: 155-157.
- 9)Oosterveer DM, Versmissen J, Yazdanpanah M, Hamza TH, Sijbrands EJ. Differences in characteristics and risk of cardiovascular disease in familial hypercholesterolemia patients with and without tendon xanthomas: a systematic review and meta-analysis. Atherosclerosis. 2009; 207: 311-317