Ali İlker FİLİZ, Kazım ŞENOL, Taner KIVILCIM, Murat Ferhat FERHATOĞLU, Abdulcabbar KARTAL

HELİCOBACTER PYLORİ ERADİKASYONU TAKİBİNDE NÖTROFİL/LENFOSİT ORANININ ÖNEMİ

GİRİŞ ve AMAÇ: Üst sindirim sistemine ait birçok hastalığın etyopatogenezinde rol oynayan helicobacter pylori insanlarda en sık görülen kronik bakteriyel enfeksiyondur. Prevalansı sosyokültürel ve coğrafi bölgelere göre değişkenlik gösteren bu patojen dünya nüfusunun %30-%50'sini etkilemektedir. Yıllar içerisine artan antibiyotik kullanımı ve sanitasyon koşullarındaki değişiklikler nedeniyle bu yaygın enfeksiyonun davranış şekli de değişiklik göstermiştir. Bu çalışmamızda birçok merkezde kolaylıkla yapılabilen bir tetkik olan tam kan sayımında bulunan ve enfeksiyon belirteci olabilecek parametreler ile helicobacter pylori enfeksiyonu arasındaki ilişkiyi inceledik. YÖNTEM ve GEREÇLER: Bu çalışmamızda Ocak 2016- Aralık 2016 üst gastrointestinal sistem endoskopisi yapılan 2939 hastanın tam kan sayımı ve patoloji verileri retrospektif olarak inceledik. BULGULAR: Helicobacter pylori varlığına göre nötrofil/lenfosit oranı arasında istatistiksel olarak anlamlı farklılık saptanmış ve helicobacter pylori (+) olguların NLR değerleri helicobacter pylori (-) olgulara göre yüksek bulunmuştur. TARTIŞMA ve SONUÇ: Nötrofil/lenfosit oranının helicobacter pylori eradikasyonu tedavi sürecini takip etmek için yararlı olabileceğini düşünmekteyiz.

Anahtar Kelimeler:

Helicobacter pylori, nötrofil/lenfosit, gastrit, eradikasyon

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