Aslı Dönmez, Murat Sayın, Cem Koray Çataroğlu, Alp Alptekin, Aysel Gezer

Granisetronun Spinal Anestezi Kaynaklı Hipotansiyona Etkisi

Amaç: Bulantı kusma profilaksisi için kullanılan intravenöz granisetronun spinal anestezi kaynak- lı hipotansiyon ve bradikardi üzerine etkisinin değerlendirilmesi amaçlandı. Yöntem: Spinal anestezi altında elektif opere edilen, ASA 1-2 sınıfında olan 120 hasta rastgele olarak Grup G (Granisetron; n=60) ve Grup P (Plasebo; n=60) gruplarına ayrıldı. Spinal anestezi- den 5 dk önce, G grubuna 10 mL %0.9 serum fizyolojikle seyreltilmiş 1 mg intravenöz granisetron ve P grubuna ise 10 mL intravenöz %0.9 serum fizyolojik uygulandı. İki gruptaki tüm hastalara 15 mg hiperbarik bupivakain %0.5 ile L4-5 seviyesinden spinal anestezi yapıldı. Motor blok derecesi ve seviyesi, sensoryal blok seviyesi ve hemodinamik veriler, anesteziden önce bir kez ve sonra ise 20 dk boyunca her 5 dk’da bir kaydedildi. Bulgular: Her iki grubun demografik verilerinde anlamlı fark yoktu. İlk değerlere göre hemodina- mik verilerde her iki grupta da düşme görülse de G grubunda sistolik, diastolik ve ortalama kan basıncı ölçümleri istatistiksel olarak anlamlı derecede daha yüksekti. Kalp atım hızında anlamlı fark gözlenmedi. Sonuç: İntravenöz olarak uygulanan granisetron spinal anestezi sonrası gelişen hipotansiyonu azaltır, ancak kalp atım hızı üzerine belirgin etkisi yoktur.

Effects of Granisetron on Spinal Anesthesia-Induced Hypotension

Objective: It was aimed to evaluate the effect of intravenous (IV) granisetron used for nausea and vomiting prophylaxis on hypotension and bradycardia caused by spinal anesthesia. Methods: 120 ASA 1-2 patients undergoing elective surgery under spinal anesthesia were randomly divided into Group G (Ganisetron; n=60) and Group P (Placebo; n=60) groups. Five minutes before spinal anesthesia, Group G received 1 mg intravenous granisetron diluted in 10 mL of isotonic sodium chloride solution and Group P received 10 mL of isotonic sodium chloride solution. Spinal anesthesia with hyperbaric bupivacaine 0.5%, 15 mg at the level of L4-5 was applied for both groups. Hemodynamic data, sensory and motor block parameters were recorded before and after spinal anaesthesia every 5 minutes during 20 minutes of surgery. Results: There was no difference in the demographic data of both groups. Although hemodynamic data showed a decrease in both groups according to initial values, blood pressure measurements in group G were significantly higher than the first measure values. There was no significant difference in heart rate values between the groups. Conclusion: Intravenous granisetron reduces hypotension after spinal anesthesia, but it has no significant effect on heart rate.

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