Cem YÜCEL, Orçun ÇELİK, Mehmet Zeynel KESKİN, Özgür ÇAKMAK, ÜLKÜ KÜÇÜK, Zafer KOZACIOĞLU

Klinefelter sendromlu ve normal karyotipli hastaların testiküler sperm ekstraksiyonu sonuçlarının karşılaştılması: 10 yıllık tek merkez deneyimi

AMAÇ: Klinefelter sendromlu (KS) ve normal karyotipli (46XY) nonobstrüktif azospermili (NOA) hastalarda mikroskopik testiküler sperm ekstraksiyonu (mTESE) sonuçlarını karşılaştırarak KS'nin mTESE sonuçlarına etkilerini ortaya koymak.GEREÇ ve YÖNTEMLER: Kurumumuzda mTESE operasyonu olan hastaların medikal verilerini retrospektif olarak inceledik. Hastalar, genetik sonuçlarına göre normal karyotipli (grup 1) ve KS'li (grup 2) olarak iki gruba ayrıldı. Bu iki grup yaş, infertilite süresi, hormon profili, mTESE'de sperm elde etme oranı ve testiküler histopatolojilerine göre karşılaştırıldı.BULGULAR: Çalışmaya 413 hasta dahil edildi. Bu hastaların yaş ortalaması 34,4±5,7 yıldı. Grup 1'deki hastaların yaş ortalaması 34,8±6,1 yıl, grup 2'deki hastaların yaş ortalaması 30,8±4,8 yıldı. İki grup arasında hasta yaşı açısından istatistiksel anlamlı farklılık yoktu (p=0,098). Testosteron düzeyi ve sperm elde etme oranı grup 1'de grup 2'ye göre istatistiksel olarak anlamlı yüksekti. Foliküler uyarıcı hormon düzeyi, luteinizan hormon düzeyi grup 2'de grup 1'e göre istatistiksel anlamlı yüksekti. İnfertilite süresi, östradiol düzeyi ve prolaktin düzeyi açısından gruplar arasında istatistiksel anlamlı farklılık saptanmadı.SONUÇ: KS'li hastalarda mTESE başarısının normal karyotipli hastalara göre daha düşük olduğu gözlendi

Comparison of testicular sperm extraction results in patients with klinefelter syndrome and normal karyotypes: 10 years single center experience

OBJECTIVE: We aimed to compare the results of microscopic testicular sperm extraction (mTESE) with Klinefelter syndrome (KS) and normal karyotype nonobstructive azoospermia (NOA) patients to determine the effects of KS on mTESE results.MATERIAL and METHODS: We retrospectively reviewed the medical data of patients with the diagnosis of NOA who had undergone the mTESE operation in our institution. According to the genetic results, patients were divided into two groups with normal karyotype (group 1) and KS (group 2). These two groups were compared according to age, duration of infertility, hormone profile, sperm retrieval rate and testicular histopathology.RESULTS: In this study, 413 patients were included. The mean age of these patients is 34.4±5.7 years. The mean age of the patients in group 1 was 34.8±6.1 years, and in group 2 was 30.8±4.8 years. There was no statistically significant difference in age between the two groups (p=0.098). Testosterone level and sperm retrieval rate were statistically higher in group 1 than in group 2. Follicular stimulating hormone level and luteinizing hormone level were statistically higher in group 2 than in group 1. There was no statistically significant difference between groups in terms of duration of infertility, estradiol level and prolactin level.CONCLUSION: In patients with KS, mTESE success was observed to be lower than in patients with normal karyotype

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