COVID-19 pandemisi ve COVID-19 aşısının menstrüel siklusa etkisi

Menstrüel siklus düzensizlikleri, menstrüel siklustaki sıklık, düzenlilik, süre veya yoğunluk açısından değişiklikleri ve ayrıca ara kanamayı içerir. Düzensiz menstrüel siklusun küresel prevalansı üreme yıllarında %5 ile %34 arasında değişmekte ve bununla ilgili sorunlar jinekoloğa en sık başvuru nedenlerinden birini oluşturmaktadır. Covid-19 pandemi süre- cinde ve covid-19 aşılarından sonra kadınlarda menstrüel düzensizlikle- rin arttığı ve ped sayılarının azaldığı belirtilmiştir. Eğer bu değişikliklerin aşı ile ilgili bir bağlantısı varsa, bunun belirli bir aşı bileşeninden ziyade aşıya karşı bağışıklık tepkisinin bir sonucu olabileceği düşünülmekte - dir. Aşılamadan sonra menstrüel siklusta bildirilen değişiklikler kısa ömürlü olsa da, bu olası advers reaksiyona ilişkin sağlam araştırmalar, aşılama programının genel başarısı için kritik olmaya devam etmektedir. Covid-19 sosyal hayatı etkilerken kadınlar özellikle cinsel aktif dönemde hormonal dengesizliklere yol açmaktadır. Bunun sonucunda da mens - trüel siklus düzensizlikleri, kullanılan ped sayısının azalması ile sonuç - lanmasına ve gelecek kuşakları tehdit edecek nüfus sayısında düşmelere neden olacak sonuçlara yol açabilir. Bu çalışmanın amacı pandemi süre- cinin başlangıcı olan Aralık 2019–2022 yılları arasında Covid-19 pan- demisi ve Covid-19 aşısı olarak geliştirilen mRNA aşısı ve adenovirüs vektörlü aşılarının hormonal bozukluklara ve menstrüel siklus düzen- sizliklerine etkilisinin araştırılması amaçlanmıştır. Literatürler PUBmed, Web of Science, Google Akademik’ten “Covid-19 pandemisi, Covid-19 aşısı, menstruasyon, menstrüel siklus düzensizliği” anahtar kelimele- ri kullanılarak kaynaklara ulaşılmış ve 14400 kaynak tanımlanmıştır. Retrospektif olan çalışmalar ve olgu sunumu olan çalışmalar dışlanarak sayı 30’a düşmüş, geriye kalanlar taranarak uygun olan bilimsel yayınlar- dan 20 sayı çalışmaya dahil edilmiştir.

Effect of COVID-19 pandemic and COVID-19 vaccine on menstrual cycle

Menstrual cycle irregularities include changes in menstrual cycle frequency, regularity, duration or intensity, as well as breakthrough bleeding. The global prevalence of irregular menstrual cycle ranges from 5% to 34% during reproductive years, and related problems constitute one of the most common reasons for referral to a gynecologist. It has been stated that during the Covid-19 pandemic and after the covid-19 vaccines, menstrual irregularities increased and the number of pads decreased in women. If these changes are related to the vaccine, it is thought that it may be a result of the immune response to the vaccine rather than a specific vaccine component. While reported changes in menstrual cycle after vaccination are short-lived, robust research on this potential adverse reaction remains critical to the overall success of the vaccination program. While Covid-19 affects social life, women cause hormonal imbalances, especially during the sexually active period. As a result, menstrual cycle irregularities may result in a decrease in the number of pads used and result in a decrease in the number of population that will threaten future generations. The aim of this study was to investigate the effects of mRNA vaccine and adenovirus vectored vaccines developed as Covid-19 pandemic and Covid-19 vaccine between December 2019–2022, the beginning of the pandemic process, on hormonal disorders and menstrual cycle irregularities. Resources were accessed from the literatures PUBmed, Web of Science, Google Academic using the keywords “Covid-19 pandemic, Covid-19 vaccine, menstruation, menstrual cycle irregularity” and 14400 references were identified. The number of retrospective studies and case reports were excluded, and the number decreased to 30, and 20 of the appropriate scientific publications were included in the study by scanning the rest.

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  • 1. Wang Y-X, Arvizu M, Rich-Edwards JW, Stuart JJ, Manson JE, Missmer SA, et al. Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study. BMJ. 2020;371:m3464. [CrossRef ]
  • 2. Fraser IS, Critchley HO, Broder M, Munro MG. The FIGO recommendations on terminologies and definitions for normal and abnormal uterine bleeding. Semin Reprod Med. 2011;29:383–90. [CrossRef ]
  • 3. Nillni YI, Wesselink AK, Hatch EE, Mikkelsen EM, Gradus JL, Rothman KJ, Wise LA. Mental health, psychotropic medication use, and menstrual cycle characteristics. Clin Epidemiol. 2018;10:1073–82. [CrossRef ]
  • 4. Cirillo PM, Wang ET, Cedars MI, Chen LM, Cohn BA. Irregular menses predicts ovarian cancer: prospective evidence from the child health and development studies. Int J Cancer. 2016;139:1009–17. [CrossRef ]
  • 5. Kwak Y, Kim Y, Baek KA. Prevalence of irregular menstruation according to socioeconomic status: A population-based nationwide cross-sectional study. PloS One. 2019;14:e0214071. [CrossRef ]
  • 6. Ansong E, Arhin SK, Cai Y, Xu X, Wu X. Menstrual characteristics, disorders and associated risk factors among female international students in Zhejiang Province, China: A cross-sectional survey. BMC Womens Health. 2019;19:35. [CrossRef ]
  • 7. Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM- COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113:3–13. [CrossRef]
  • 8. Jung E-K, Kim S-W, Ock S-M, Jung K-I, Song C-H. Prevalence and related factors of irregular menstrual cycles in Korean women: the 5th Korean National Health and Nutrition Examination Survey (KNHANES-V, 2010-2012). J Psychosom Obstet Gynaecol. 2018;39:196–202. [CrossRef ]
  • 9. Schoep ME, Nieboer TE, van der Zanden M, Braat DD, Nap AW. The impact of menstrual symptoms on everyday life: a survey among 42, 879 women. Am J Obstet Gynecol. 2019;220:569. [CrossRef ]
  • 10. Phelan N, Behan LA, Owens L. The impact of the COVID-19 pandemic on women’s reproductive health. Front Endocrinol (Lausanne). 2021;12:642755. [CrossRef ]
  • 11. Toufexis D, Rivarola MA, Lara H, Viau V. Stress and the reproductive axis. J Neuroendocrinol. 2014;26:573–86. [CrossRef ]
  • 12. Mayerhofer A, Dissen GA, Costa ME, Ojeda SR. A role for neurotransmitters in early follicular development: induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary. Endocrinology. 1997;138:3320–9. [CrossRef ]
  • 13. Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514–23. [CrossRef ]
  • 14. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13. [CrossRef ]
  • 15. World Health Organization (WHO). Coronavirus Disease (COVID-19) Dashboard; 2020. https://covid19.who.int
  • 16. Pierce M, Hope H, Ford T, Hatch S, Hotopf M, John A, et al. Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population. Lancet Psychiatry. 2020;7:883–92. [CrossRef ]
  • 17. McGinty EE, Presskreischer R, Han H, Barry CL. Psychological distress and loneliness reported by US adults in 2018 and April 2020. JAMA. 2020;324:93–4. [CrossRef ]
  • 18. Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, et al. Analysis of sex hormones and menstruation in COVID-19 women of child- bearing age. Reprod Biomed Online. 2021;42:260–7. [CrossRef ]
  • 19. Demir O, Sal H, Comba C. Triangle of COVID, anxiety and menstrual cycle. J Obstet Gynaecol. 2021;41:1257–61. [CrossRef ]
  • 20. Takmaz T, Gundogmus I, Okten SB, Gunduz A. The impact of COVID 19 related mental health issues on menstrual cycle characteristics of female healthcare providers. J Obstet Gynaecol Res. 2021;47:3241–9. [CrossRef ]
  • 21. Shufelt C, Torbati T, Dutra E. Hypothalamic amenorrhea and the long-term health consequences. Semin Reprod Med. 2017;35:256– 62. [CrossRef ]
  • 22. Nelson AL, Ritchie JJ. Severe anemia from heavy menstrual bleeding requires heightened attention. Am J Obstet Gynecol. 2015;213:97.e1–6. [CrossRef ]
  • 23. Banikarim C, Chacko MR, Kelder SH. Prevalence and ımpact of dysmenorrhea on Hispanic female adolescents. Arch Pediatr Adolesc Med. 2000;154:1226–9. [CrossRef ]
  • 24. Dennerstein L, Lehert P, Heinemann K. Epidemiology of premenstrual symptoms and disorders. Menopause Int. 2012;18:48–51. [CrossRef ]
  • 25. Yuksel B, Ozgor F. Effect of the COVID-19 pandemic on female sexual behavior. Int J Gynaecol Obstet. 2020;150:98–102. [CrossRef ]
  • 26. Aolymat I. A cross-sectional study of the impact of COVID-19 on domestic violence, menstruation, genital tract health, and contraception use among women in Jordan. Am J Trop Med Hyg. 2021;104:519–25. [CrossRef ]
  • 27. Bruinvels G, Goldsmith E, Blagrove R, Martin D, Shaw L, Piasecki J. How lifestyle changes within the COVID-19 global pandemic have affected the pattern and symptoms of the menstrual cycle. medRxiv. 2021. [CrossRef ]
  • 28. Pirkis J, John A, Shin S, DelPozo-Banos M, Arya V, Analuisa- Aguilar P, et al. Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries. Lancet Psychiatry. 2021;8:579–88. [CrossRef ]
  • 29. World Bank. Menstrual hygiene management enables women and girls to reach their full potential. Feature story: May 25, 2018. https://www.worldbank.org/en/news/feature/2018/05/25/ menstrual-hygiene-management
  • 30. Babbar K, Martin J, Ruiz J, Parray AA, Sommer M. Menstrual health is a public health and human rights issue. Lancet Public Health. 2022;7:e10–1. [CrossRef ]
  • 31. Medicines and Healthcare Products Regulatory Agency. Research and analysis. Coronavirus vaccine-weekly summary of yellow card reporting. Updated 3 February 2023. https://www.gov. uk/government/publications/coronavirus-covid-19-vaccine- adverse-reactions/coronavirus-vaccine-summary-of-yellow-card- reporting#annex-1-vaccine-analysis-print
  • 32. Suzuki S, Hosono A. No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study. Papillomavirus Res. 2018;5:96–103. [CrossRef ]
  • 33. Muhaidat N, Alshrouf MA, Azzam MI, Karam AM, Al-Nazer MW, Al-Ani A. Menstrual symptoms after COVID-19 vaccine: a cross-sectional investiga tion in the MENA region. Int J Womens Health. 2022;14:395–404. [CrossRef ]
  • 34. Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur J Endocrinol. 2005;152:501–13. [CrossRef ]
  • 35. Monin L, Ushakov DS, Arnesen H, Bah N, Jandke A, Muñoz- Ruiz M, et al. γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis. Mucosal Immunol. 2020;13:969–81. [CrossRef ]
  • 36. Male V. Effect of COVID-19 vaccination on menstrual periods in a retrospectively recruited cohort. medRxiv. 2021. [CrossRef ]
  • 37. Kinik E, Özcan H. COVID-19 aşı sonrası görülen menstrual semptomların değerlendirilmesi. 2. Mediterranean Scientific Research and Innovation Congress. 2022;809–13. https://www. researchgate.net/publication/362697241_COVID-19_ASI_ SONRASI_GORULEN_MENSTRUAL_SEMPTOMLARIN_ DEGERLENDIRILMESI
  • 38. Demir O, Sal H, Comba C. Triangle of COVID, anxiety and menstrual cycle. J Obstet Gynaecol. 2021;41:1257–61. [CrossRef ]
  • 39. Speed B. Young women are the unlikely new face of covid-19 vaccine resistance. i News; 2021. https://inews.co.uk/news/ health/coronavirus-latest-experts-debunk-vaccine-fertility-myths- women-819783
Androloji Bülteni-Cover
  • ISSN: 2587-2524
  • Yayın Aralığı: 4
  • Başlangıç: 1999
  • Yayıncı: Turgay Arık