Benign prostat hiperplazisi ile ilişkili alt üriner sistem yakınmalarının tedavisinde tadalafil 5 mg’ın etkinliği

BPH ile ilişkili bu alt üriner sistem yakınmalarının tedavisinde tadalafil 5 mg son yıllarda klinik kullanıma girmiş medikal tedavi seçeneklerinden bir tanesidir. Bu derlemede tadalafil 5 mg'ın BPH/AÜSY için klinik kullanıma girişi ve etkinliği anlatılmaktadır

Efficacy of tadalafil 5 mg in the treatment of benign prostatic hyperplasiarelated lower urinary tract symptoms

In the treatment of BPH-related lower urinary tract symptoms, tadalafil 5 mg is of the medical treatment options that have been used clinically in recent years. In this review, introduction to clinical use and efficacy of tadalafil 5 mg for BPH/LUTS is described

___

  • 1. Gravas S, Bach T, Bachmann A, et al. EAU Guidelines on the Management of non-Neurogenic Male Lower Urinary Tract Symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO) European Association of Urology 2015.
  • 2. Sairam K, Kulinskaya E, McNicholas TA, et al. Sildenafil influences lower urinary tract symptoms. BJU Int 2002;90:836–9.
  • 3. Mulhall JP, Guhring P, Parker M, Hopps C. Assessment of the impact of sildenafil citrate on lower urinary tract symptoms in men with erectile dysfunction. J Sex Med 2006;3:662–7. doi: 10.1111/j.1743-6109.2006.00259.x
  • 4. Govorov A, Kasyan G, Priymak D, et al. Tadalafil in the management of lower urinary tract symptoms: a review of the literature and current practices in Russia. Cent European J Urol 2014;67:167–77. doi: 10.5173/ceju.2014.02.art10
  • 5. Seftel AD, de la Rosette J, Birt J, et al. Coexisting lower urinary tract symptoms and erectile dysfunction: a systematic review of epidemiological data. Int J Clin Pract 2013;67:32–45. doi: 10.1111/ijcp.12044
  • 6. Rosen R, Altwein J, Boyle P, et al. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol 2003;44:637–49.
  • 7. Tinel H, Stelte-Ludwig B, Hütter J, Sandner P. Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms. BJU Int 2006;96:1259–63. doi: 10.1111/j.1464-410X.2006.06501.x
  • 8. Filippi S, Morelli A, Sandner P, et al. Characterization and functional role of androgen-dependent PDE5 activity in the bladder. Endocrinology 2007;148:1019–29. doi: 10.1210/ en.2006-1079
  • 9. Andersson KE, de Groat WC, McVary KT, et al. Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: pathophysiology and mechanism(s) of action. Neurourol Urodyn 2011;30:292–301. doi: 10.1002/nau.20999
  • 10. Gacci M, Andersson KE, Chapple C, et al. Latest Evidence on the Use of Phosphodiesterase Type 5 Inhibitors for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia. Eur Urol 2016;70:124–33. doi: 10.1016/j. eururo.2015
  • 11. Laydner HK, Oliveira P, Oliveira CR, et al. Phosphodiesterase 5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a systematic review. BJU Int 2010;107:1104– 9. doi: 10.1111/j.1464-410X.2010.09698.x
  • 12. Liu L, Zheng S, Han P, Wei Q. Phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a systematic review and meta-analysis. Urology 2011;77:123–9. doi: 10.1016/j.urology.2010.07.508
  • 13. McVary KT, Monnig W, Camps JL Jr, et al. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trial. J Urol 2007;77:1071–7. doi: 10.1016/j.juro.2006.10.055
  • 14. Gacci M, Vittori G, Tosi N, et al. A randomized, placebocontrolled study to assess safety and efficacy of vardenafil 10 mg and tamsulosin 0.4 mg vs. tamsulosin 0.4 mg alone in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Sex Med 2012;9:1624–33. doi: 10.1111/j.1743- 6109.2012.02718.x
  • 15. Yan H, Zong H, Cui Y, Li N, Zhang Y. The efficacy of PDE5 inhibitors alone or in combination with alpha-blockers for the treatment of erectile dysfunction and lower urinary tract symptoms due to benign prostatic hyperplasia: a systematic review and metaanalysis. J Sex Med 2014;11:1539–45. doi: 10.1111/jsm.12499
  • 16. Zhang LT, Park JK. Are phosphodiesterase type 5 inhibitors effective for the management of lower urinary symptoms suggestive of benign prostatic hyperplasia? World J Nephrol 2015;4:138–47. doi: 10.5527/wjn.v4.i1.138
  • 17. Roehrborn CG, Chapple C, Oelke M, Cox D, Esler A, Viktrup L. Effects of tadalafil once daily on maximum urinary flow rate in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. J Urol 2014;191:1045–50. doi: 10.1016/j. juro.2013.10.074
  • 18. Hatzimouratidis K. A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Ther Adv Urol 2014;6:135–147. doi: 10.1177/1756287214531639
  • 19. Chapple CR, Roehrborn CG, McVary K, Ilo D, Henneges C, Viktrup L. Effect of tadalafil on male lower urinary tract symptoms: an integrated analysis of storage and voiding international prostate symptom subscores from four randomised controlled trials. Eur Urol 2015;67:114–22. doi: 10.1016/j.eururo.2014.08.072
  • 20. Oelke M, Shinghal R, Sontag A, Baygani SK, Donatucci CF. Time to onset of clinically meaningful improvement with tadalafil 5 mg once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: analysis of data pooled from 4 pivotal, double-blind, placebo controlled studies. J Urol 2015;193:1581– 9. doi: 10.1016/j.juro.2014.11.094
  • 21. Porst H, Oelke M, Goldfischer ER, et al. Efficacy and safety of tadalafil 5 mg once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: subgroup analyses of pooled data from 4 multinational, randomized, placebo-controlled clinical studies. Urology 2013;82:667–73. doi: 10.1016/j. urology.2013.05.005
  • 22. Donatucci CF, Brock GB, Goldfischer ER, et al. Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia:a 1-year, open-label extension study. BJU Int 2011; 107:1110–6. doi: 10.1111/j.1464- 410X.2010.09687.x