Travma sonrası stres bozukluğu hastalarında travma tipinin plazma C-reaktif protein düzeyi ile ilişkisi

Amaç: Kronik psikiyatrik bir bozukluk olan travma sonrası stres bozukluğu (TSSB) ile C-reaktif protein (CRP) düzeyi arasındaki ilişkiyi araştıran çalışmalar tutarsız sonuçlara sahiptir. Bildiğimiz kadarıyla TSSB ilişkili travma tipinin, plazma CRP düzeyi üzerine etkisini inceleyen çalışma yoktur. Bu çalışma TSSB’nin ve TSSB ilişkili travma tipinin plazma CRP düzeyine etkisini saptamak amacıyla planlanmıştır. Yöntem: Bu kesitsel çalışmanın örneklemini, 73 TSSB hastası ve 69 sağlıklı kontrol olgusu oluşturmaktadır. Katılımcılardan usulüne uygun kan alındıktan sonra, klinisyen tarafından uygulanan TSSB Ölçeği (CAPS) katılımcılara uygulanmış ve Sosyodemografik Veri Formu, Beck Depresyon Ölçeği (BDÖ) ve Dissosiyatif Yaşantılar Ölçeği (DES) içeren bir form doldurmaları istenmiştir. Bulgular: TSSB hastalarının CRP, BDÖ ve DES puanları sağlıklı kontrollere göre istatistiksel olarak yüksek bulun- muştur. Farklı travma tiplerine göre plazma CRP düzeyi, CAPS ve DES puanları arasında istatistiksel olarak anlamlı farklılıklar bulunmuştur. İkili grup karşılaştırılmalarında, iş kazası kaynaklı TSSB hastalarının plazma CRP düzeyleri, diğer travma tiplerine bağlı TSSB hastalarından istatiksel olarak daha yüksekti. Sonuç: Sonuç olarak TSSB hasta- ları ile sağlıklı kontrol grubu arasında, plazma CRP düzeyi farklılıkları olduğunu ve plazma CRP düzeyinin TSSB ilişkili travma tipi ile değişebileceğini öneren sonuçları saptadık. (Anadolu Psikiyatri Derg 2019; 20(6):573-580)

The relation of trauma type on the levels of plasma C-reactive protein in patients with post-traumatic stress disorder

Objective: Studies investigating the relationship between posttraumatic stress disorder (PTSD) that is chronic psychiatric disorder and C-reactive protein (CRP) level have inconsistent results. However, to our knowledge, there is no study investigating the effect of PTSD-related trauma type on plasma CRP levels. This study was planned to determine the effect of PTSD and PTSD-related trauma type on plasma CRP levels. Methods: The sample of this cross-sectional study consisted of 73 PTSD patients and 69 healthy control subjects. After proper blood collection, Clinician-Administered PTSD Scale (CAPS) was administered by the researchers and Sociodemographic Data Form, Beck Depression Inventory (BDI) and Dissociative Experiences Scale (DES) were requested. Results: CRP, BDI and DES scores of PTSD patients were statistically higher than healthy controls. There were statistically signifi- cant differences between plasma CRP level, CAPS and DES scores according to different trauma types. In the comparison of bilateral groups, plasma CRP levels of occupational accident-induced PTSD patients were statis- tically higher than patients with PTSD due to other types of trauma. Conclusion: As a result, there were differences in plasma CRP levels between PTSD patients and healthy control group and plasma CRP levels were found to vary with the type of trauma associated with PTSD. (Anatolian Journal of Psychiatry 2019; 20(6):573-580)

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