Selective serotonin re-uptake inhibitors (SSRIs) are commonly used in the clinical practice of child and adolescent psychiatry because of reasonable safety and tolerability. In the literature, extrapyramidal system symptoms (EPS) induced by SSRI use are more frequently reported in adults, but are rarely reported in children. In this report, we report acute cervical dystonia that occurs due to sertraline dose increase and does not recur after dose reduction in a 12-year-old adolescent girl. Although sertraline-induced cervical dystonia in children and adolescents has been reported as several case reports, our case is the first case occurring on the first day after a dose increase. (Ana- tolian Journal of Psychiatry 2019; 20(6):667-669)
Seçici serotonin gerialım inhibitörleri, güvenli olması ve tolere edilebilirliği nedeniyle çocuk ve ergen psikiyatrisi klinik pratiğinde yaygın olarak kullanılmaktadır. Literatürde seçici serotonin gerialım inhibitörleri SSRI kullanımına bağlı ekstrapiramidal sistem belirtiler erişkinde daha sık bildirilmiş olup çocuklarda nadir olarak sunulmuştur. Biz bu yazı- da, 12 yaşında ergen bir kızda sertalin doz artışına bağlı ortaya çıkan ve dozun azaltılmasından sonra yinelemeyen akut servikal distoni olgusunu sunuyoruz. Çocuk ve ergenlerde sertraline bağlı servikal distoni birkaç olgu sunumu olarak bildirilmiş olmakla birlikte, olgumuz doz artışı sonrası ilk günde ortaya çıkan ilk olgudur. (Anadolu Psikiyatri Derg 2019; 20(6):667-669)
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Henry A, Kisicki MD, Varley C. Efficacy and safety of antidepressant drug treatment in children and adolescents. Mol Psychiatry 2012; 17:1186-1193.
Hawthorne JM, Caley CF. Extrapyramidal reac-tions associated with serotonergic antidepres-sants. Ann Pharmacother 2015; 4: 1136-1152.
Madhusoodanan S, Alexeenko L, Sanders R, Brenner R. Extrapyramidal symptoms associated with antidepressants-a review of the literature and an analysis of spontaneous reports. Ann Clin Psychiatry 2010; 2:148-156.
Fahn S, Marsden CD, Calne DB. Classification and investigation of dystonia. CD Marsden, S Fahn (Eds.), Movement Disorders, second ed., London: Butteworths, 1987, pp.332-358.
Govoni S, Racchi M, Masoero E, Zamboni M, Ferini-Strambi L. Extrapyramidal symptoms and antidepressant drugs: neuropharmacological as-pects of a frequent interaction in the elderly. Mol Psychiatry 2001; 6:134-142.
Hetrick SE, McKenzie JE, Cox GR, Simmons MB, Merry SN. Newer generation antidepressants for depressive disorders in children and adolescents. Cochrane Database Syst Rev 2012; 14:11.
Raveendranathan D, Rao SG. Sertraline induced acute mandibular dystonia. J Neurosci Rural Pract 2015; 6:586.
Lambert MT, Trutia C, Petty F. Extrapyramidal adverse effects associated with sertraline. Prog Neuropsychopharmacol Biol Psychiatry 1998; 22:741-748.
Yazıcı KU, Perinçel İ. Cervical dystonia associ-ated with sertraline in an adolescent a case. Firat Med J 2014; 19:53-55.
Ayaydın H, Bozkurt H. Spasmodic torticollis asso-ciated with sertraline in a child and an adolescent. Turk J Pediatr 2015; 57:109-111.
Özcan A, Uytun MÇ, Uytun S, Poyrazoğlu HG.Dystonia of neck and oculogyric dystonic reaction due to sertraline use. Anatolian Journal of Psychi-atry 2015; 16:378.
Wang LF, Huang JW, Shan SY, Ding JH, Lai JB, Xu Y, et al. Possible sertraline-induced extra-pyramidal adverse effects in an adolescent. Neuropsychiatr Dis Treat 2016; 12:1127-1129.
Baykara S. Oromandibular dystonia with sertraline treatment: a case report. Anatololian Journal of Psychiatry 2017; 18:59-61.