Decreased olfactory bulb volume in patients with restless legs syndrome

Objective: Restless legs syndrome (RLS) is a chronic progressive movement disorder with a pathophysiology that is still not fully known. In recent years, a growing number of studies have suggested that the disease may be of a neurodegenerative nature. We aimed to measure olfactory bulb volume (OBv) in RLS using cranial magnetic resonance imaging (MRI). Methods: The study included 24 patients (11 males, 13 females) aged 18-60 years who were diagnosed with idiopathic RLS according to the criteria of the Restless Legs Syndrome Study Group (IRLSSG) 2014 and followed up by our neurology clinic, and 26 age-matched controls (12 males, 14 females). In the cranial MRI examination of both groups, the right, left and total OBv values were manually calculated in mm3 . Results: While there was no significant difference between the right and left OBv values of the patient and control groups, the total OBv value of the patient group was found to be significantly lower compared to the control group (p=0.041). There was no significant difference between disease severity and OBv values. It was seen that right, left and total OBv values decreased significantly as the duration of the disease increased (p=0.001, p

Huzursuz bacak sendromu hastalarında azalmış olfactor bulbus volümü

Amaç: Huzursuz bacaklar sendromu (HBS) patofizyolojisi tam olarak bilinmeyen kronik, ilerleyici bir hareket bozukluğudur. Son yıllarda artan sayıdaki çalışmalar hastalığın nörodejeneratif doğada olabileceğini düşündürmüştür. Biz de HBS’de olası nörodejenerasyonu kraniyal manyetik rezonans görüntüleme (MRI) ile olfactor bulbus volümünü (OBV) değerlendirerek araştırmayı amaçladık. Yöntem: Çalışmaya nöroloji kliniğimizde izlenen 18-60 yaşları arasındaki kadın ve erkeklerden oluşan ve Restless Legs Syndrome Study Group (IRLSSG) 2014 tanı ölçütlerine göre idiopatik huzursuz bacak sendromu tanısı konan 24 hasta (11 E, 13 K), ve 18-60 yaşları arasındaki kadın ve erkeklerden oluşan 26 kontrol grubu (12 E, 14 K) alındı. İki grubun kraniyal MRI incelemesinde sağ, sol ve toplam OBV değeri mm3 cinsinden, manuel olarak hesaplanarak karşılaştırılmıştır. Bulgular: Ölçülen sağ ve sol OBV değerlerinde hasta ve kontrol grupları arasında anlamlı fark saptanmazken, hasta grubunun toplam OBV değeri kontrol grubuyla karşılaştırıldığında anlamlı derecede düşük bulundu (p=0.041). Sağ, sol ve toplam volüm değerleri arasında hastalık şiddetine göre anlamlı fark bulunmadı. Hastalık süresi uzadıkça sağ, sol ve toplam OBv değerlerinin anlamlı olarak azaldığı saptandı (p=0.001, p

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