Erkan KILINÇ, Yaşar DAĞISTAN, Emine DAĞISTAN, Zeliha COŞGUN

Lomber disk hernisi ve hemogram parametreleri arasında bir bağlantı var mıdır?

Amaç: İnflamatuar mekanizmalar disk hernisi ile ilişkili bel ağrısının patogenezinde önemli bir rol oynamaktadır. Rutin hemogram testlerindeki yeni ve umut vadeden inflamatuar markörler ortalama trombosit hacmi (MPV) ve kırmızı küre dağılım genişliği (RDW)’ dir. Sunulan çalışmada lomber disk hernili hastaların (LDH) MPV ve RDW değerlerinin sağlıklı gönüllülerle ve lomber disk hernisi açısından radyolojik bulguları olmayan siyataljili semptomatik hastalarla karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Sunulan retrospektif çalışma Abant İzzet Baysal Üniversitesi Eğitim ve Araştırma Hastanesinin nöroşirürji anabilim dalında gerçekleştirildi. Kontrol (n=57), LDH (n=73) ve siyatalji (n=20). olmak üzere üç grup oluşturuldu. Grupların beyaz küre (WBC), hemoglobin (Hb), hematokrit (Htc), ortalama korpüsküler hacim (MCV), platelet sayısı (PLT), RWD ve MPV parametreleri değerlendirildi.Bulgular: LDH, siyatalji ve kontrol gruplarının ortalama MPV değerleri sırasıyla 9.3 ± 1.8 fL, 8.2 ±1.1fL ve 8.4 ±1.0fL olarak bulundu. LDH grubunun ortalama MPV değeri siyatalji ve kontrol gruplarından önemli derecede daha yüksekti (p=0.001). LDH, siyatalji ve kontrol gruplarının ortalama RDW değerleri sırasıyla 14.8±1.8, 13.8±1.0 ve 13.7±1.2 olarak bulundu. LDH grubunun ortalama RDW değeri de siyatalji ve kontrol gruplarından önemli derecede daha yüksekti (p=0.001). Tartışma ve Sonuç: Yükselmiş MPV ve RDW değerleri siyataljili hastalardaki LDH’ nin güçlü indikatörleri olabilirler ve bu yükselmiş değerlere sahip hastalar görüntüleme çalışmaları için öncelikli olarak düşünülmelidirler. Bununla birlikte bulgularımızı destekleyen daha fazla prospektif çalışmaya ihtiyaç vardır.

Anahtar Kelimeler:

ortalama trombosit hacmi, kırmızı küre dağılım genişliği, inflamasyon, lomber disk hernisi

Is there a link between lumbar disc herniation and haemogram parameters?

Aim: Inflammatory mechanisms play a key role in the pathogenesis of back pain related to disc hernia. Novel and promising inflammatory markers in routine hemogram tests are mean platelet volume (MPV) and red cell distribution width (RDW). We aimed to compare the MPV and RDW values of lumbar disc herniation (LDH) patients with healthy subjects and the symptomatic patients with sciatalgia but without radiological evidence of lumbar disc herniation.Materials and Methods: This retrospective cohort study was carried out in the department of neurosurgery of Abant Izzet Baysal University Education and Research Hospital. We designed three groups including control (n=57), LDH (n=73) and sciatalgia (n=20). Hemogram parameters containing white blood cell count (WBC), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), RDW, platelet count (PLT), and MPV of the subjects of control, LDH and sciatalgia groups were evaluated. Results: Mean MPV of the LDH, sciatalgia and control groups were 9.3 ± 1.8 fL, 8.2 ±1.1fL and 8.4 ±1.0fL, respectively. Mean MPV values of LDH group were significantly higher than sciatalgia and control groups(p=0.001). Mean RDW values of the LDH, sciatalgia and control groups were 14.8 ± 1.8, 13.8 ±1.0 and 13.7 ±1.2, respectively. Mean RDW values of LDH group were also significantly higher than sciatalgia and control groups (p=0.001). Discussion and Conclusion: We think that elevated MPV and RDW should be strong indicators of LDH in patients with sciatalgia and they should be considered prior to imaging studies. However, more prospective studies supporting our results are needed.

Keywords:

Mean platelet volume, red cell distribution width, inflammation, lumbar disc hernia,

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