Esma DEMİRHAN, Sevgi ATAR, Muhammed Bilal ÖZDEMİR, Ömer KURU

Aksiyal spondiloartritli hastalarda D vitamini eksikliğinin yorgunluk ve depresyon üzerine etkisi

Amaç: Bu çalışmada aksiyal spondiloartrit (Ax-SpA) hastalarında D vitamini eksikliğinin yorgunluk ve depresyon üzerine etkisini incelemeyi amaçladık. Yöntemler: Bu kesitsel çalışmaya 141 Ax-SpA hastası dahil edildi. Hastaların demografik bilgileri kaydedildi. Hastaların depresyon, anksiyete, ağrı, yorgunluk ve hastalık aktivite düzeylerini değerlendirmek için, sırasıyla Hastane Anksiyete ve Depresyon Ölçeği, Görsel Analog Ölçeği, Yorgunluk Şiddeti Ölçeği ve Ankilozan Spondilit Hastalık Aktivite Skoru kullanıldı. D vitamini düzeyleri eksiklik (<10 ng/ml), yetersizlik (11-20 ng/ml) ve normal (>20 ng/ml) olarak sınıflandırıldı. Bulgular: Araştırmaya toplam 141 hasta (67 kadın, 74 erkek) katılmıştır. D vitamini düzeyi olguların %14.2’sinde eksik, %56’sında yetersiz ve %29.8’inde yeterliydi. Yorgunluk değerlendirmesinde olguların %20,6’sı normal, %60,3’ü yorgun, %19,1’i kronik yorgun olarak değerlendirildi. Ax-SpA hastalarının %79,4’ünde yorgunluk tespit edilmesine rağmen yorgunluk skorlarının D vitamini eksikliği ile ilişkili olmadığı görüldü (p=0,191). D vitamini grupları (eksiklik, yetersizlik ve normal) arasında yorgunluk ve depresyon skorları, cinsiyet, hastalık süresi ve aktivitesi açısından anlamlı fark yoktu. Sonuç: Ax-Spa’lı hastalarda D vitamini eksikliği yorgunluk, depresyon veya hastalık aktivitesi ile ilişkili değildir. D vitamini eksikliğinden bağımsız olarak, depresyon ve yorgunluk şikayeti olan hastalar uygun şekilde değerlendirilmeli ve tedavi edilmeli, D vitamini eksikliğinin tedavisi de göz ardı edilmemelidir.

Anahtar Kelimeler:

Depresyon, D vitamini eksikliği, spondiloartrit, yorgunluk

The effect of vitamin D deficiency on fatigue and depression in patients with axial spondyloarthritis

Aim: In this study, we aimed to examine the effect of vitamin D deficiency on fatigue and depression in patients with axial spondyloarthritis (Ax-SpA). Methods: This cross-sectional study included 141 Ax-SpA patients. Demographic information of the patients was recorded. The Hospital Anxiety and Depression Scale, Visual Analog Scale, Fatigue Severity Scale, and Ankylosing Spondylitis Disease Activity Score were used to evaluate depression, anxiety, pain, fatigue, and disease activity levels, respectively. Vitamin D levels were classified as deficiency (<10 ng/ml), insufficiency (11–20 ng/ml), and normal (>20 ng/ml). Results: A total of 141 patients enrolled in the study (67 female and 74 male). Vitamin D levels were deficient in 14.2%, insufficient in 56%, and sufficient in 29.8% of cases. In the evaluation of fatigue, 20.6% of the cases were evaluated as normal, 60.3% as tired, and 19.1% as chronically tired. Although fatigue was detected in 79.4% of Ax-SpA patients, fatigue scores were not associated with vitamin D deficiency (p=0.191). There were no significant differences between the vitamin D groups (deficiency, insufficiency, and normal) in fatigue and depression scores, sex, disease duration, and activity. Conclusion: Vitamin D deficiency is not associated with fatigue, depression, or disease activity in patients with Ax-Spa. Regardless of vitamin D deficiency, patients with depression and fatigue should be evaluated and managed appropriately, and the management of vitamin D deficiency should not be ignored.

Keywords:

Depression, fatigue, spondyloarthritis, vitamin D deficiency,

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