Zeytin Yaprağının (Olea europaea L.) Diyabetik Sıçanlarda Bazı Biyokimyasal ve Hematolojik Parametreler Üzerine Etkisi

Bu çalışma, değişik oranlardaki zeytin yaprağı ekstraktının (Olive Leaf Extract-OLE) ve infüzyonunun streptozosin ile oluşturulmuş deneysel diyabetik sıçanların bazı biyokimyasal ve hematolojik parametreleri üzerine olası koruyucu etkisini araştırmak amacıyla planlanmıştır. Bu amaç doğrultusunda, 56 adet Wistar albino sıçan rastgele 7 gruba ayrıldı (n=8). 21 günlük deneme sonunda biyokimyasal ve hematolojik analizleri yapıldı. OLE uygulanan grupların hepsinde RBC’ler istatiksel anlamda etkilenmezken, HBG, HCT, MCV’nin pozitif yönde etkilendiği görüldü (p

Effects of Olive Leaf (Olea europaea L.) Extract on Some Biochemical and Haematological Parameters in Diabetic Rats

This study was aimed to investigate the possible protective effects of different amount of olive leaf extracts and infusion on some biochemical and haematological parameters of streptozocin-induced experimental diabetic rats. For this purpose, 56 Wistar albino rats were randomly divided into 7 groups (n=8). Biochemical and haematological analyses were performed at the end of the 21-day trial. It was observed that HGB, HCT, MCV were positively affected (p

PDF

___

Al-Azzawie, H.F., Alhamdani, MS., 2006. Hypoglycemicand antioxidanteffect of oleuropein in alloxan-diabeticrabbits. Life Sci, 78, 1371-7.
Andreadou, I., Iliodromitis, E.K., Mikros, E., Constantinou, M., Agalias, A., Magiatis, P., Skaltsounis, A.L., Kamber, E., Tsantili-Kakoulidou, A. and Kremastinos, D.T, 2006. The olive constituentol europein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits. Journal of Nutrition, 136, 2213-2219.
Baynes, R.D., Lamparellı, R.D.V., Chetty, N., Atkınson, P., Bezwoda, W.R.A. ve Gear, J., 1988. Platelet parameters: Part II. Platelet volume-number relationships in various normal and disease states. SAMJ, 73, 39–43.
Beyazit, Y., Sayilir, A., Torun, S., Suvak, B., Yeşil, Y. and Purnak, T., 2012. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol, 36, 162-8.
Chandra, A., Mahdi, A.A., Ahmad, S. and Singh, R.K., 2007. Indian herbs result in hypoglycemic responses in streptozotocin induced diabetic rats. Nutr. Res, 27, 161-168.
Choi, J.W., Pai, S.H., 2004. Influences of hypercholesterolemia on red cell indices and erythrocyte sedimentation rate in elderly persons. Clin Chima Acta, 341, 117-121.
Eidi, E., Eidi, M., Darzi, R., 2009. Antidiabetic effect of Olea europaea L. in normal and diabetic Rats. Phytotherapy Research, 23, 347-350.
Gao, L.P., Li, Z., Guo, Z.Y., 2013. The effects of vitamin Con DDP-induced anemia in rats. Toxicol Mech Methods, 23, 383–388.
Gayathrı, M., Kannabıran, K., 2009. The Effects of Oral Administration of an Aqueous Extract of Ficus bengalensis Stem Bark on Some Hematological and Biochemical Parameters in Rats with Streptozotocin-Induced Diabetes. Turk J Biol, 33, 9-13.
Geyikoglu, F., Colak, S., Turkez, H., Bakır, M. and Koç, K., 2016. Oleuropein Ameliorates Cisplatin-induced HematologicalDamages Via Restraining Oxidative Stress and DNA Injury. Indian J Hematol Blood Transfus, DOI 10.1007/ s12288-016-0718-3
Ginsberg, H.N., 1999. Identification and treatment of hypertri-glyceridemia as a risk factor for coronary heart disease. Curr Cardiol Rep, 1: 2337.
Karthikesan, K., Pari, L. ve Menon, V.P., 2010. Combined treatment of tetrahydro curcumin and chlorogenic acid exert spotential antihyperglycemic effect on streptozotocin nicotinamide induced diabeticrats. Gen. Physiol. Biophys, 29, 23–30.
Kayaalp, O., 2002. Rasyonel tedavi yönünden tıbbi farmakoloji. Onuncu baskı, Hacettepe-TAŞ, Ankara.
Khayyal, M.T., El-Ghazaly, M.A., Abdallah, D.M., Nassar, N.N., Okpanyi, S.N. and Kreuter, M.H., 2002. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung, 52, 797–802.
Klein, R., 1995. Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care, 18, 258–268.
Mahmoud, A.M., 2013. Hematological alterations in diabetic rats-role of adipocytokines and effect of citrus flavonoids. EXCLI Journal, 12, 647-57.
Maimoona, A., Naeem, I., Saddiqe, Z. and Jameel, K., 2011. A review on biological, nutraceutical and clinical aspects of French maritimepine bark extract. J.Ethnopharmacol,133, 261-277.
Meurs, I., Hoekstra, M., Van Wanrooij, E.J.A., Hildebrand, R.B, Kuiper, J., Kuipers, F., Hardeman, M.R., Van Berkel, T.J.C. and Van Eck, M., 2005. HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes. Exp Hematol, 33, 1309-1319.
Özbek, H., Cengiz, N., Him, A., Uğraş, S., Özgökçe, F. ve Erdoğan, E., 2006. Yüksek kolesterollü diyetle beslenen sıçanlarda Foeniculum vulgare P. mill. (rezene) tohumlarının kan kolesterol seviyesi üzerine etkis, Genel Tıp Derg,16, 177-180.
Soler-Rivas, C., Espin, J.C. and Wichers, H.J., 2000. Oleuropein and related compounds. Journal of Agricultural and Food Chemistry, 80, 1013-1023.
Somova, L.I., Shode, F.O., Mipando, M., 2004. Cardiotonic and antidysrhyth-mic effects of leanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine, 11, 121-129.
Tancrède, G., Rousseau-Migneron, S. and Nadeau, A., 1983. Long-term changes in the diabetic state induced by different doses of streptozotocin in rats. British Journal of Experimental Pathology, 64, 117-123.
Tedesco, I., Russo, M., Russo, P., Carraturo, A., Faruolo, C., Moio, L. and Palumbo, R., 2000. Antioxidant effect of red wine polyphenols on red blood cells. J Nutr Biochem, 11, 114–119.
Thomas, R.M., 2002. Oxidative stress and lipid in diabetes. A role in endothelium vasodilator dysfunction. Vasc Med, 1, 195–204.
Yılmaz, B., 2000. Fizyoloji. Canlılık olaylarıyla ilgili fiziksel ve kimyasal kurallar, beden sıvıları, kan, bağışıklık, alerji, lenf, kemik iliği ve kan dolaşımı, Ankara.