Dilek BOZKURT, Fazilet HIZ, Meral ÇINAR, Meltem CAN

Paget hastalığında alendronat tedavisine yanıt veren başağrısı olgusu

Paget hastalığı kemik ağrısı, deformitesi, patolojik kırıklar, nörolojik bulgularla (başağrısı, işitme kaybı, tinnitus vb.) kendini gösteren kronik, fokal bir iskelet hastalığıdır. İleri yaş grubunda sık görülür. Etyolojisinde viral ve genetik faktörler rol oynar. Hastaların çoğu asemptomatiktir. Tanı sıklıkla radyografi çekilirken rastlantısal bir bulgu olarak veya beklenmeyen serum alkalen fosfataz yüksekliği ile konur. Gelişebilecek kemik deformiteleri ve nörolojik komplikasyonlar nedeniyle yaşam kalitesi olumsuz etkilenir. Bu nedenle erken tanı ve tedavi önem taşır. Tedavide en sık kullanılan ilaçlar bifosfanatlardır. Bu yazıda, başağrısı yakınması ile başvuran ve Paget hastalığı tanısı alan bir olgu sunuldu. Paget hastalığının tanı ve tedavisi, nörolojik komplikasyonları literatür ışığında gözden geçirildi.

Headache case that responded to alendronate treatment in Paget's disease

Pagets disease of the bone is a chronic, focal skeletal disease characterized by bone pain and deformity, pathological fractures and neurological symptoms such as headache, hearing loss and tinnitus, etc. The frequency of the disease increases in later ages. Viral and genetical factors play a role in the etiology. The majority of cases are asymptomatic. It is often diagnosed with an incidental finding on radiography or with an unexpected high serum alkaline phosphatase level. Bone fractures or neurological complications can negatively affect the quality of life. Early diagnosis and treatment are thus very important. Bisphosphonates are the most frequently used medication in the treatment. We present a case who sought medical help because of headache and was diagnosed as Pagets disease. Neurological complications and the diagnosis and treatment of Pagets disease are reviewed in the literature.

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