Kronik kanser ağrısı tedavisinde kullanılan transdermal fentanilin geriatrik ve erişkin yaş grubunda karşılaştırılması

Amaç: Transdermal fentanil (TDF) günümüzde kronik kanser ağrısının tedavisinde sıklıkla tercih edilen bir ajandır. Biz, çalışmamızda TDF’in analjezik etkinliğini, yan etki sıklığını ve hasta memnuniyetini, erişkin ve geriatrik hasta grubunda karşılaştırmayı hedefledik. Gereç ve Yöntem: Ağrı polikliniğimizde takip edilen hastalar içerisinden kriterlere uyan 181 hastanın verileri (TDF kullanımı ile başlayan 4 aylık dönem) geriye dönük olarak taranarak çalışmaya alındı. Hastalar yaşlarına göre Grup E (Grup Erişkin; 18 ile 65 yaş arası, n=95) ve Grup G (Grup Geriatrik; 65 yaş üstü, n=86) olarak iki gruba ayrıldı. Hastaların demografik özellikleri, kanser türleri, kanser ağrısı çekme süreleri, vizüel analog skala (VAS) skorları, tedavi değerlendirme skalası (TDS) skorları, kullandıkları TDF dozu, belirttikleri yan etkiler ve TDF tedavisi sonlandırılan hasta sayısı kaydedildi. Bulgular: Her iki grupta da TDF kullanımı sonrası ağrı şiddetinde azalma saptandı (p

Comparison of transdermal fentanyl for the management of cancer pain in adults and elders

Objectives: The transdermal fentanyl (TDF) patch has become widely used in the treatment of cancer pain. We aimed to compare the analgesic efficiency, side effects and patient satisfaction of TDF in adult and geriatric patients. Methods: The data of 181 patients who were observed in our pain clinic were included in this retrospective study. There were 95 patients in the adult group (Group A) and 86 patients in the geriatric group (Group G). Demographic data, cancer type, duration of pain, side effects, visual analog scale (VAS) score, treatment assessment scale (TAS) score, TDF dosage, and the number of patients in whom therapy has been terminated were recorded. Results: After the usage of TDF, reduction in pain score was observed in both groups (p<0.001). The TAS score was similar between the groups at the end of the first month, but it was lower in Group G in the following months. Constipation, dry mouth, somnolence, and dyspnea were seen more frequently in Group G. Because of these side effects, the number of patients in whom therapy was terminated was higher in Group G. Conclusion: The TDF patch is a good choice for cancer pain treatment for both adult and geriatric patients. Since it was observed that the incidence of side effects was higher in the geriatric patients, they should be treated more carefully.

Kaynakça

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