Nöropatik ağrı tedavisinde duloksetin ile ortaya çıkan hiperprolaktinemi ve galaktore

Duloksetin çeşitli hastalıklarda kronik ağrı tedavisinde sık olarak kullanılılan serotonin-noradrenalin geri alım inhibitörüdür. Hiperprolaktinemi ve galaktore bu tedavinin nadir görülen bir yan etkisidir. Burada, multipl skleroz tanısı olan 34 yaşında bir kadın hastada ağrı ve duygu durum bozukluğu nedeni ile duloksetin kullanımı ve medikal tedviye bağlı gelişen galaktore olgusunu sunmaktayız.

Hyperprolactinemia and galactorrhea with duloxetine in neuropathic pain management

Duloxetine is a serotonin-norepinephrine reuptake inhibitor that is widely used in chronic pain treatment in various diseases. Hyperprolactinemia and galactorrhea are rare side effects of this medication. Here, we reported a 34-year-old female with multiple sclerosis who used duloxetine for pain management and mood disorder and experienced galactorrhea.

___

  • 1. Vilar L, Vilar CF, Lyra R, Freitas MD. Pitfalls in the diagnostic evaluation of hyperprolactinemia. Neuroendocrinology 2019;109(1):7–19.
  • 2. Trenque T, Herlem E, Auriche P, Drame M. Serotonin reup- take inhibitors and hyperprolactinaemia: A case/non-case study in the French pharmacovigilance database. Drug Saf 2011;34(12):1161–6.
  • 3. Coker F, Taylor D. Antidepressant-induced hyperprolacti- naemia: İncidence, mechanisms and management. CNS Drugs 2010;24(7):563–74.
  • 4. Curone M, Tullo V, Savino M, Proietti-Cecchini A, Bussone G, D’Amico D. Outcome of patients with chronic migraine with medication overuse and depression after duloxetine: İnfluence of coexisting obsessive compulsive disorder. Neurol Sci 2013;34 Suppl 1:S175–7.
  • 5. Ferraro D, Plantone D, Morselli F, Dallari G, Simone AM, Vitetta F, et al. Systematic assessment and characterization of chronic pain in multiple sclerosis patients. Neurol Sci 2018;39(3):445–53.
  • 6. Demirci S, Unubol M, Demirci K. Galactorrhea with normal prolactin levels associated with duloxetine. J Clin Psycho- pharmacol 2015;35(3):346–7.
  • 7. Grigg J, Worsley R, Thew C, Gurvich C, Thomas N, Kulkarni J. Antipsychotic-induced hyperprolactinemia: Synthesis of world-wide guidelines and integrated recommendations for assessment, management and future research. Psycho- pharmacology (Berl) 2017;234(22):3279–97.
  • 8. Korkmaz S, Kuloglu M, Isık U, Saglam S, Atmaca M. Galac- torrhea during duloxetine treatment: A case report. Turk Psikiyatri Derg 2011;22(3):200–1.
  • 9. Belli H, Akbudak M, Ural C. Duloxetine-related galactor- rhea and restless legs syndrome: A case report. Psychiatr Danub 2013;25(3):266–7.
  • 10. Ashton AK, Longdon MC. Hyperprolactinemia and ga - lactorrhea induced by serotonin and norepinephrine reuptake inhibiting antidepressants. Am J Psychiatry 2007;164(7):1121–2
Ağrı-Cover
  • ISSN: 1300-0012
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2018
  • Yayıncı: Ali Cangül