Analgesic effect of Anatolian propolis in mice

Amaç: Bu çalışmanın amacı periodontal hastalıklarda profilaktik bileşen olarak eklenen Anadolu propolisinin analjezik etkisinin değerlendirilmesidir. Gereç ve Yöntem: Su, etanol ve asetondan ekstre edilmiş Anadolu propolisi hazırlandı. Ekstrelerin analjezik etkisi fare tail-flick testi ile değerlendirildi (n=6 her bir ekstre için). Gruplar arası karşılaştırmalar için tek yönlü ANOVA, sonrasında ise data grupları ortalamalarının arasındaki belirgin farkların saptanması amacıyla post-hoc Scheffe's testi uygulandı. P

Farelerde Anadolu propolisinin analjezik etkisi

Objective: The aim of the present study was to assess the analgesic effect of Anatolian Propolis, which is added to toothpastes as a prophylactic component for periodontal diseases. Methods: Water, ethanol and acetone extracted Anatolian Propolis were prepared. Analgesic effect of the extracts was assessed using the tail-flick test in mice (n=6 per each extract). Comparison among groups were made by using one-way ANOVA, followed by post-hoc Scheffe's test to determine significant differences among the means of the data groups. P<0.05 was accepted as significant difference. Results: We found that water extracted Anatolian Propolis caused a significant increase, 1.61 fold increase (p<0.001 versus control), of the latency time using tail-flick test in mice. However, acetone extracted and ethanol extracted propolis led no significant effect. Conclusion: We proved the analgesic effect of water extracted Anatolian Propolis. Thus, propolis used in the composition of toothpastes may be beneficial in terms of its analgesic action in addition to its other favorable effects.

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