Calvarial Hyperostosis Syndrome in an American Pit Bull Terrier

Calvarial hyperostosis syndrome (CHS), which has been recently defined in juvenile dogs, is a rare, non-neoplastic, proliferative bone disease characterized by the swelling of the skull. Until recently, it was mostly reported in young Bullmastiffs with a sexual preference for male dogs. The objective of this study was to describe the clinical and pathological aspects of the condition as a contribution to literature due to its rarity in dogs. The paper presents the first reported case of Calvarial hyperostosis in turkey. A four-month-old female American Pit bull terrier was presented to the veterinary physician with the complaints of painful swelling on the head, loss of appetite, lethargy and fever. Radiograph of the skull revealed diffuse thickening of the frontal and parietal bones and markedly increased bone opacity, and magnetic resonance imaging (MRI) scans revealed increased diploe thickness in all sequences. The preliminary clinical diagnosis of calvarial hyperostosis was confirmed by histopathology which revealed the presence of both immature woven bone and mature bone trabeculae separated by prominent basophilic cementing lines. The lesion is self-limiting, and most cases show spontaneous regression in few months, but in this case the patient was monitored until one year of age and no regression was seen.

Amerikan Pit Bull Terrier bir Köpekte Calvarial Hiperosteozis Sendromu

Kalvarial Hiperosteozis (KHO) son yıllarda genç köpeklerde tanımlanmış olan ve nadir olarak görülen kafatası kemiğinde şişme ile karekterize neoplastik olmayan proliferative bir kemik hastalığıdır. Bu hastalık daha çoğunlukta genç erkek Bull Mastiff lerde bildirilmiştir. Çalışmada, Literatürde köpeklerde nadir olarak bildirilen bu sendromun klinik ve patolojik yönleriyle açıklanması amaçlanmıştır. Bu makale Köpeklerde Kalvarial Hiperosteozis konusunda Türkiyede ilk yayındır. Dört aylık dişi bir Amerikan Pit Bull Terrier köpek yüksek ateş, iştahsızlık, durgunluk ve kafada agrılı şişlik şikayeti ile kliniğe getirildi. Kranium’un radyografik incelemesinde frontal ve parietal kemiklerde yaygın kalınlaşma ve kemik opazitesinde belirgin artış, manyetik rezonans (MR) görüntülenmesinde tüm kesitlerde diploe mesafesinde artış saptandı. Klinik olarak kalvarial hiperosteozis olduğu düşünülen bu olgu , histopatolojik inceleme ile doğrulandı. Mikroskobik incelemede ortamda geniş-kalın trabeküllerden oluşan kompakt bir kemik yapısı saptandı. Kemiğin tam olgunlaşmamış woven kemik ile olgunlaşmış trabeküllerden oluştuğu ve bu iki kemik yapısı arasında bazofilik görünümde belirgin bir sement hattı saptandı.

Kaynakça

Alexander, J.W., 1983. Selected skeletal dysplasias: craniomandibular osteopathy, multiple cartilaginous exostoses and hypertrophic osteodystrophy. Veterinary Clinics of North America: Small Animal Practice 13, 55-70. [CrossRef]

De Heer, N., Maltha, J.H.J., Van Garderen, E., 2015. Calvarial hyperostosis syndrome in a young Weimaraner dog. Vlaams Diergeneeskunding Tijdschrift 84, 154-157.

Gensure, R.C., Makite, O., Barclay, C., 2005. A novel COLIA1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. Journal of Clinical Investigation 115, 1250-1257. [CrossRef]

Glorieux, F.H., 2005. Caffey disease: an unlikely collagenopathy. Journal of Clinical Investigation 115, 1142-1144. [CrossRef]

Gülanber, E.G., Özer, K., Gürel, A., 2001. Doberman Irkı Bir Köpekte KranioMandibular Osteopati. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 27(2), 393-400.

Huchkowsky, S.L., 2002. Craniomandibular osteopathy in a bullmastiff. The Canadian Veterinary Journal 43(11), 883-885.

Kamoun-Goldrat, A., Le Merrer, M., 2008. Infantile cortical hiperosteosis (Caffey disease): a review. Journal of Oral and Maxillofacial Surgery 66, 2145-2150. [CrossRef]

Mathes, R.L., Holmes, S.P., Coleman, K.D., Radlinsky, M.A., Moore, P.A., 2012. Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. Veterinary Ophthalmology 15(4), 263-270. [CrossRef]

McConnell, J.F., Hayes A., Platt S.R., Smith K.C., 2006. Calvarial Hyperostosis syndrome in two bullmastiffs. Veterinary Radiology and Ultrasound 47(1), 72-77. [CrossRef]

Milli, Ü., Hazıroğlu, R., 1997. Veteriner Patoloji 1. Cilt; 3. Bölüm, Kemik hastalıları, Sayfa; 399-403., Tamer Matbaacılık, DemetEvler, Ankara

Muir, P., Dubielzig, R.R., Johnson, K.A., Shelton, G.D., 1996. Hypertrophic osteodystrophy and calvarial hyperostosis. Compendium on Continuing Education for the Practicing Veterinarian 18, 143-151.

Pastor, K.F., Boulay, J.P., Schelling S.H., Carpenter, J.L., 2000. Idiopathic heyperostosis of the calvaria in five young bullmastiffs. Journal of the American Animal Hospital Association 36(5), 439-445. [CrossRef]

Thompson, D.J., Rogers, W., Owen, M.C., Thompson, K.G., 2011. Idiopathic canine juvenile cranial hyperostosis in a Pit Bull Terrier. New Zeland Veterinary Journal 59(4), 201-205. [CrossRef]

Varallo, G.R., Lima, B.R., Raposo, T.M.M., Daleck, C.R., 2012. Craniomandibular osteopathy in English Bulldog. Arsive Veterinaria, jaboticabal, SP 28(4), 218-221.

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