Murat Altay, Kenan BAYRAKCI, HÜSEYİN YUSUF YILDIZ, Yener SAĞLIK

Radyoterapi uygulanan fibröz displazili bir olguda osteosarkom gelişimi

Fibröz displazi (FD) zemininde sarkom gelişmesi nadirdir ve polyostotik olgularda dönüşüm daha sıktır. Bu yazıda, polyostotik FD tanısından 28 yıl sonra sol tibiasında osteosarkom gelişen 41 yaşında bir erkek hasta sunuldu. Osteosarkom FD nedeniyle uygulanan radyoterapiden 20 yıl sonra gelişmişti. Diz üstü amputasyon yapılan hasta ameliyattan sekiz ay sonra öldü. Bu olguda radyoterapinin FD tedavisinde yarar sağlamadığı görüldü ve sarkom gelişmesinin radyoterapiyle ilişkili olabileceği düşünüldü.

Anahtar Kelimeler:

Kemiğin fibröz displazisi, Fibröz displazi, poliostotik, Osteosarkom

The development of osteosarcoma following radiotherapy for fibrous dysplasia

Sarcoma arising from fibrous dysplasia (FD) is rare and it is more common in polyostotic type. In this case report, we present a 41-year-old male patient who developed osteosarcoma of the left tibia 28 years after the initial diagnosis and 20 years after radiation therapy for FD. He underwent above-knee amputation, but died eight months after surgery. This case suggests that radiotherapy has no beneficial effect in the treatment of FD and that it may be associated with the development of sarcoma.

Keywords:

Fibrous Dysplasia of Bone, Fibrous Dysplasia, Polyostotic, Osteosarcoma,

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