The Factors Related to the 6 Minute Walk Test: The Experience of a Referral Lung Transplantation Center
The Factors Related to the 6 Minute Walk Test: The Experience of a Referral Lung Transplantation Center
Objectives: The 6-minute-walk test is a practical and widely used test, which indicates the exercise capacity in patients with a severe pulmonary disease. The study aims to investigate the related factors with the 6-minute-walk test in lung transplantation candidates. Materials and Method: The data were collected retrospectively from 349 patients, between January 2012 and September 2020. The patients were grouped according to their underlying lung disease as obstructive lung diseases, interstitial lung diseases, and infective lung diseases. The data collected included patient demographics, gender, body mass index, artery blood gas, the results of the respiratory function test, six-minute walk test, long-term oxygen therapy, and the need for non-invasive mechanical ventilation [such as group 1 (6MWD
___
- [1] ATS statement: guidelines for the six-minute walk test. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. Am J Respir Crit Care Med 2002;166(1):111-117.)
- [2] Holden DA, Rice TW, Stelmach K, et al. Exercise testing, 6-min walk, and stair climb in the evaluation of patients at high risk for pulmonary resection. Chest. 1992;102(6):1774- 1779.
- [3] Pierce RJ, Copland JM, Sharpe K, et al. Preoperative risk evaluation for lung cancer resection: predicted postoperative product as a predictor of surgical mortality. Am J Respir Crit Care Med. 1994;150(4):947-955.
- [4] Marjanski T, Wnuk D, Bosakowski D, et al. Patients who do not reach a distance of 500 m during the 6-min walk test have an increased risk of postoperative complications and prolonged hospital stay after lobectomy. Eur J Cardiothorac Surg. 2015;47(5): e213-e219.
- [5] Chaikriangkrai K, Jhun HY, Graviss EA, et al. Overweight- mortality paradox and impact of six-minute walk distance in lung transplantation. Ann Thorac Med. 2015;10(3):169- 175.
- [6] Castleberry AW, Englum BR, Snyder LD, et al. The utility of preoperative six-minute-walk distance in lung transplantation. Am J Respir Crit Care Med. 2015;192(7):843-852.
- [7] Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official statement of the European respiratory Society. Eur Respir J Suppl 1993;16: 5e40.
- [8] Egan TM, Murray S, Bustami RT, Shearon TH, et al. Development of the new lung allocation system in the United States. Am J Transplant 2006; 6:1212-1227.
- [9] Celli BR, Cote CG, Marin JM, Casanova C, et al. The body- mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004; 350:1005-1012.
- [10] Cote CG, Casanova C, Marín JM, et al. Validation and comparison of reference equations for the 6-min walk distance test. Eur Respir J 2008; 31:571-578.
- [11] Martinu T, Babyak MA, O’Connell CF, et al. Baseline 6-min walk distance predicts survival in lung transplant candidates. Am J Transplant 2008; 8:1498-1505.
- [12] Lederer DJ, Arcasoy SM, Wilt JS, et al. Six-minute-walk distance predicts waiting list survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006;174(6):659-664.
- [13] Kawut SM, O’Shea MK, Bartels MN, et al. Exercise testing determines survival in patients with diffuse parenchymal lung disease evaluated for lung transplantation. Respir Med. 2005;99(11):1431-1439.
- [14] Lama VN, Flaherty KR, Toews GB, et al. Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia. Am J Respir Crit Care Med. 2003;168(9):1084-1090.
- [15] Karanth MS, Awad NT. Six Minute Walk Test: A Tool for Predicting Mortality in Chronic Pulmonary Diseases. J Clin Diagn Res. 2017;11(4): OC34-OC38.
- [16] Pinto-Plata VM, Cote C, Cabral H, Taylor J, Celli BR. The 6-min walk distance: change over time and value as a predictor of survival in severe COPD. Eur Respir J. 2004;23(1):28-33.
- [17] Dajczman E, Wardini R, Kasymjanova G, Préfontaine D, Baltzan MA, Wolkove N. Six minute walk distance is a predictor of survival in patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation. Can Respir J. 2015;22(4):225-229.
- [18] du Bois RM, Weycker D, Albera C, et al. Six-minute-walk test in idiopathic pulmonary fibrosis: test validation and minimal clinically important difference. Am J Respir Crit Care Med. 2011;183(9):1231-1237.
- [19] Tuppin MP, Paratz JD, Chang AT, et al. Predictive utility of the 6-minute walk distance on survival in patients awaiting lung transplantation. J Heart Lung Transplant. 2008;27(7):729-734.