Investigation of Mean Platelet Volume as a Prognostic Criterion in Non-Healing Wounds

Investigation of Mean Platelet Volume as a Prognostic Criterion in Non-Healing Wounds

Objective: We aimed to evaluate if the Mean Platelet Volume (MPV) is an acute phase reactant in non-healing wounds, by analyzing its correlation with Erythrocyte Sedimentation Rate (ESR). Method: Our study was carried out in a descriptive type with the participation of patients with non-healing wounds. The laboratory data and characteristics of the patients were accessed retrospectively, and the obtained data were recorded in the data recording form. Results: The sample group consisted of 92 patients with non-healing wounds. 26.9% of the patients with non-healing wounds had pressure sores, 37.6% of them had diabetic foot wounds, 18.3% had non-healing wounds developed after trauma, and 17.2% had necrotizing fasciitis. The average age of the patients was 53.22±19.13, and the average length of stay in the hospital was 108.98±18.78 (min 3 months, max 6 months) days. The MPV value, which was found to be high in the early stages of non-healing wounds, decreased after the wound was completely healed. When the MPV value was compared to ESR, an acute phase reactant, a positive and strong statistically significant correlation was found between MPV and ESR based on the result of this correlation analysis (r=0.256, p

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  • [1] Sheng L, Zhang Z, Zhang Y, Wang E, Ma B, Xu Q, et al. A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing. Biomaterials 2021;264:120414.
  • [2] Catanzano O, Quaglia F, Boateng JS. Wound dressings as growth factor delivery platforms for chronic wound healing. Expert Opinion on Drug Delivery 2021.
  • [3] Sun G, Zhang X, Shen YI, Dickinson LE, Fox-Talbot K, Reinblatt M, Steenbergen C, Harmon JW, Gerecht S. Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing. Proc Natl Acad Sci USA 2011; 108(52):20976-81.
  • [4] Briquez PS, Clegg LE, Martino MM, Gabhann FM, Hubbell JA. Design principles for therapeutic angiogenic materials, Nat Rev Mater 2016;1(1):15006.
  • [5] Russell MJ, Daniel RM, Hall AJ. On the emergence of life via catalytic ironsulfide membranes. Terra Nova 1993; 5(4):343-34
  • [6] Linke B, Schreiber Y, Picard-Willems B, et al., Activated platelets induce an anti-inflammatory response of monocytes/macrophages through cross-regulation of PGE2 and cytokines. Mediators of Inflammation 2017;14.
  • [7] Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators of inflammation. 2019.
  • [8] Zimmet J, Ravid K. Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte platelet system. Experimental Hematology 2000;28(1):3- 16.
  • [9] Slavka G, Perkmann T, Haslacher H, et al., Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology 2011;31(5):1215-18.
  • [10] Shah B, Oberweis B, Tummala L, et al., Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention. American Journal of Cardiology 2013:111(2):185-89.
  • [11] Feng Y, Yin H, Mai G, et al., Elevated serum levels of CCL17 correlate with increased peripheral blood platelet count in patients with active tuberculosis in China. Clinical and Vaccine Immunology 2011;18(4):629-32.
  • [12] Koç S, Eyibilen A, Erdoğan AS. Mean platelet volume as an inflammatory marker in chronic sinusitis. European Journal of General Medicine 2011;8(4):314-17.
  • [13] Gasparyan AY, Sandoo A, Stavropoulos-Kalinoglou A, Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-α therapy. Rheumatology International 2010;30(8):1125-29.
  • [14] Yavuz S, Ece A. Mean platelet volume as an indicator of disease activity in juvenile SLE. Clinical Rheumatology 2014;33(5):637-641.
  • [15] Li N, Yu Z, Zhang X, et al. Elevated mean platelet volume predicts poor prognosis in colorectal cancer. Scientific Reports 2017;7(1):10261.
  • [16] Yin JB, Wang X, Zhang X, Liu L, Wang RT. Mean platelet volume predicts survival in pancreatic cancer patients with synchronous liver metastases. Scientific Reports 2018;8(1):6014.
  • [17] Rollini F, Franchi F, Muñiz-Lozano A, Angiolillo DJ. Platelet function profiles in patients with diabetes mellitus. Journal of Cardiovascular Translational Research 2013;6(3):329-45.
  • [18] Liu S, Ren J, Han G, et al. Mean platelet volume: a controversial marker of disease activity in Crohn’s disease. European Journal of Medical Research, 2012;17(1):27.
  • [19] Zubcevic N, Mesihovic R, Zubcevic S. Usefulness of laboratory data in estimation of Crohn’s disease activity. Medical Archives 2010;64(1):33-36.
  • [20] Lippi G, Mattiuzzi C, Comelli I, Cervellin G. Mean platelet volume in patients with ischemic heart disease: meta- analysis of diagnostic studies. Blood Coagul Fibrinolysis 2013; 24:216-219.
  • [21] Turfan M, Erdogan E, Ertas G, Duran M, Murat SN, Celik E, et al. Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients. Blood Coagul Fibrinolysis 2013; 24:55-58.
  • [22] Cay N, Ipek A, Gumus M, Birkan Z, Ozmen E. Platelet activity indices in patients with deep vein thrombosis. Clin Appl Thromb Hemost 2012;18:206-10.
  • [23] Cao X, Xie X, Zhou J, Yang P, Wang Y, Chen Z. Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China. Hypertens Res 2012;35:903-908.
  • [24] Lippi G, Salvagno GL, Targher G, Guidi GC. Relationship between mean platelet volume and biochemical components of the metabolic syndrome. Clin Drug Investig 2007; 27:731-32.
  • [25] Aksoy S, Kilickap S, Hayran M, Harputluoglu H, Koca E, Dede DS, et al. Platelet size has diagnostic predictive value for bone marrow metastasis in patients with solid tumors. Int J Lab Hematol 2008; 30:214-19.
  • [26] Thompson CB. Selective consumption of large platelets during massive bleeding. BMJ (Clin Res Ed) 1985; 291:95- 96
  • [27] Robbins G, Barnard DL. Mean platelet volume changes in infection. J Clin Pathol 1983; 36:1320.
  • [28] Xu J, Cheng F, Li Y, Zhang J, Feng S, Wang P. Erythrocyte Sedimentation Rate Combined With the Probe-to- Bone Test for Fast and Early Diagnosis of Diabetic Foot Osteomyelitis. The International Journal of Lower Extremity Wounds 2020.
  • [29] Kutlucan A. Eritrosit Sedimentasyon Hızı ve Klinik Kullanımı [Erythrocytes Sedimentation Rate and Clinical Use]. Konuralp Tıp Dergisi 2012;4(3):73-76
Acta Medica-Cover
  • ISSN: 2147-9488
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: HACETTEPE ÜNİVERSİTESİ
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