Is Human Vomeronasal Organ A Myth or A Neglected Structure?

Is Human Vomeronasal Organ A Myth or A Neglected Structure?

The human vomeronasal organ (VNO) is a structure situated under the anteroinferior side of the nasal septum. It is mainly described in the rodents and found as a part of the accessory olfactory system. It has been shown to consist of specialized olfactory sensory cells, which function in perception of pheromones. With a large number of literature on the human VNO, there is little concensus of its persistence and functionality in human. During a routine dissection of nasal cavity, we recognized a one-sided vomeronasal pit in one of the six fresh-frozen cadavers (17 %) and described the position and structure of this rare structure morphologically. The present study summarizes the literature about the VNO and describes its structural and functional findings.

___

  • [1] Stoyanov GS, Matev BK, Stoyanov P, et al. The Human Vomeronasal (Jacobson’s) Organ: A Short Review of Current Conceptions, With an English Translation of Potiquet’s Original Text. Cureus 2018;10(5): e2643.
  • [2] Trotier D. Vomeronasal organ and human pheromones. Eur Ann Otorhinolaryngol Head Neck Dis 2011;128:184- 190.
  • [3] Nodari F, Hsu FF, Fu X, et al. Sulfated steroids as natural ligands of mouse pheromone sensing neurons. J Neurosci 2008;28:6407-6418.
  • [4] Leinders-Zufall T, Ishii T, et al. Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat Neurosci 2009;12:1551-1558.
  • [5] Touhara K. Sexual communication via peptide and protein pheromones. Curr Opin Pharmacol 2008;8:759-764.
  • [6] Bhatnagar KP and Smith TD. The human vomeronasal organ. V. An interpretation of its discovery by Ruysch, Jacobson, or Kölliker, with an English translation of Kölliker (1877). Anat Rec B New Anat 2003;270:4-15.
  • [7] Bhatnagar KP and Reid KH. The human vomeronasal organ - I: Historical perspectives. A study of Ruysch’s (1703) and Jacobson’s (1811) reports on the vomeronasal organ with comparative comments and English translations. Biomed Res 1996(7);pp.219-229.
  • [8] D’Aniello B, Semin GR, Scandurra A, et al. The vomeronasal organ: a neglected organ. Frontiers in Neuroanatomy 2017;11:70.
  • [9] Kölliker A. Über die Jacobson’schen Organe des Menschen. Leipzig: Wilhelm Engelmann. 11 p + 2 plates with explanation of figures. 1877.
  • [10] Jacobson L. Description anatomique d’un organe observe dans le mammiferes. Ann Mus Hist Natl 1811;18:412–424.
  • [11] Potiquet M. Le canal de Jacobson. Rev Laryngol 1891;2:737–753.
  • [12] Smith TD, Siegel MI, Mooney MP, et al. Prenatal growth of the human vomeronasal organ. Anat Rec 1997;248:447– 455.
  • [13] Wray S. From nose to brain: development of gonadotrophinreleasing hormone-1 neurones. J Neuroendocrinol 2010; 22:743–753.
  • [14] Trotier D, Eloit C, Wassef M, et al. The vomeronasal cavity in adult humans. Chem Senses 2000;25:69–380.
  • [15] Bhatnagar KP and Smith TD. The human vomeronasal organ. III. Postnatal development from infancy to the ninth decade. J Anat 2001;199:289–302.
  • [16] Meredith M. Human vomeronasal organ function: a critical review of best and worst cases. Chem Senses 2001;26:433- 445.
  • [17] Smith TD, Siegel MI, Burrows AM, et al. Searching for the vomeronasal organ of adult humans: preliminary findings on location, structure, and size. Microsc Res Techn 1998;41:483-491.
  • [18] Zbar RI, Zbar LI, Dudley C, et al. A classification schema for the vomeronasal organ in humans. Plast Reconstr Surg 2000;105(4):1284-1288.
  • [19] Moran DT, Jafek BW, Rowley III JC. The vomeronasal (Jacobson’s) organ in man: ultrastructure and frequency of occurrence.J Steroid Biochem Molec Biol 1991;39:1545- 1552.
  • [20] Smith TD, Buttery TA, Bathnagar KP, et al. Anatomical position of the Vomeronasal Organ in postnatal humans. Ann Anat 2001;183:475-479.
  • [21] Jacob S, McClintock MK. Psychological state and mood effects of steroidal chemosignals in women and men. Horm Behav 2000;37:57-78.
  • [22] Abolmaali ND, Kühnau D, Knecht M, et al. Imaging of the Human Vomeronasal Duct. Chem Senses 2000;26(1):35- 39.
Acta Medica-Cover
  • ISSN: 2147-9488
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: HACETTEPE ÜNİVERSİTESİ
Sayıdaki Diğer Makaleler

The Impact of Covid-19 Pandemic on the Clinical Course of Pediatric Skin Disorders: A Cross-Sectional Study

Ecem BOSTAN

Is Human Vomeronasal Organ A Myth or A Neglected Structure?

Ayşegül FIRAT, Özlem ÖNERCİ ÇELEBİ, Hatice Mürvet HAYRAN

A Case of Crimean-Congo Haemorrhagic Fever (CCHF) Mimicking the COVID-19 Disease

Zahit TAŞ, Meliha Çağla SÖNMEZER, Gülçin TELLİ DİZMAN, Ahmet Çağkan İNKAYA, Ömrüm UZUN, Murat AKOVA

Morphometry in Classification of Hippocampal Sclerosis

Güneş GÜNER, Figen SÖYLEMEZOĞLU

The Effect of Statin Use on In-Hospital Mortality in Covid-19 Patients

Abdurrahman AKYÜZ, Burhan ASLAN, Ferhat IŞIK, Murat ÇAP, İlyas KAYA, Özgür ATLI, Ümit İNCİ, Ercan TAŞTAN, Önder BİLGE, Metin OKŞUL, Mehmet Zülküf KARAHAN

Bioinformatic Analysis of Expression Pattern and Prognostic Value of Oxidoreductase ERO1L in Pancreatic Cancer

Begüm KOCATÜRK

In silico Activity and Target Prediction Analyses of Three Triazolothiadiazine Derivatives

Ceren SUCUARLI, Birsen TOZKOPARAN, Sevim Peri AYTAÇ

Are COVID-19 Vaccine Preference and COVID-19 Risk Differ in Individuals Living with HIV from The Normal Population?

Aliye BAŞTUĞ, Çağlayan Merve AYAZ

Effects of the COVID-19 Pandemic on Patients with Schizophrenia Spectrum Disorders

Elçin ÖZÇELİK EROĞLU, M. İrem YILDIZ, A. Elif Anıl YAĞCIOĞLU, Özge TÜRKOĞLU, Oğuz Kaan YALÇINKAYA, Aygün ERTUĞRUL, Sevilay KARAHAN, M. Kâzım YAZICI

Event-free Survival in Patients with Chronic Myeloid Leukemia Receiving Front-line Imatinib Mesylate

Olgu ERKİN ÇINAR, Salih AKSU, Yahya BÜYÜKAŞIK, Nesrin Damla EYÜPOĞLU, Nilgün SAYINALP, Haluk DEMİROĞLU, Hakan GÖKER, Osman İlhami ÖZCEBE, İbrahim C. HAZNEDAROĞLU