Tevfik OĞUREL, Reyhan OĞUREL, Murat ATABEY ÖZER, Zafer ONARAN

Antiglokomatöz İlaç Kullanan Glokom Hastalarında Oküler Yüzey Hastalığının Değerlendirilmesi

Amaç: Topikal antiglokomatöz ilaç kullanan glokom hastalarında oküler yüzey hastalığını (OYH) değerlendirmekHastalar ve Yöntem: Çalışmaya herhangi bir değişik tipte glokomu olan ve en az 6 aydır glokom ilacı kullanan 18 yaş üstü 83 hastanın 159 gözü çalışmaya dâhil edildi. Oküler yüzey hastalık endeks(OSDI) anketi hastalara tek tek sorularak dolduruldu. Sonrasında hastalarda oküler yüzeyi klinik olarak değerlendirmek için schirmer testi (anestezili), gözyaşı kırılma zamanı(GKZ) ve korneal boyanmaya bakıldı.Bulgular: Çalışmaya 51 erkek 32 kadın hastanın 159 gözü dâhil edildi. Erkeklerin yaş ortalaması 64,51±9,07 bayanların yaş ortalaması 54,32±11,44 idi. Hastaların ortalama ilaç kullanım süreleri 6,35±5,63 yıldı. Hastaların %36,5’i tek ilaç ,%32,1’i iki ilaç, %13,8’i üç ilaç ve %17,6’sı dört ilaç kullanmaktaydı. OSDI anketi kullanılarak kuru göz semptomları değerlendirilen hastaların %3,8’i normal, % 15,7’si hafif, %22,6’sı orta ve %57,9 şiddetli kuru göz hastası olarak değerlendirildi. Tüm hastaların ortalama OSDI skoru 46,80±19,44’tü. Schirmer testi gözlerin %34,1’inde 5 mm’nin altında saptandı. GKZ gözlerin % 52,3’de hafif,%29,5’de orta, %8,5,de şiddetli olarak değerlendirildi. Korneal boyanma açısından değerlendirildiğinde ise gözlerin %13,2’da normal boyanma, %39,6’de hafif boyanma, %23,3’de orta derecede boyanma ve %23,9’da ise şiddetli boyanma mevcuttu. Sonuç: OYH'nın teşhis edilmesinde, sadece OSDI anketinin kullanılmasının yanı sıra, gözyaşı kalitesini ve stabilitesini gösteren testleri de içeren bir testin kullanılması da sağlıklı olacaktır.

Anahtar Kelimeler:

Glokom, Antiglokomatöz İlaçlar, Oküler Yüzey Hastalığı

Evaluation of Ocular Surface Disease in Glaucoma Patients Using Topical Antiglaucomatous Agents

Aim: Evaluation of ocular surface disease (OSD) in glaucoma patients using topical antiglaucomatous agentsPatients and Method: 159 eyes of 83 patients at the age 18 years or over, who had any types of different glaucoma and had been using antiglaucomatous agents for at least 6 months were included in the study. The Ocular Surface Disease Index (OSDI) questionnaire was filled by asking patients individually. Afterwards, in order to examine ocular surface clinically, patients underwent the Schirmer test(under anesthesia) evaluation, tear break-up time(TBUT) and corneal staining. Results: A total of 159 eyes from 51 male and 32 female patients were included in the study. The average age of men was 64,51 ± 9,07 and the average age of women was 54,32 ± 11,44. Mean duration of medication use of the patients was 6.35 ± 5.63 years. 36.5% of the patients had single medication, 32.1% had two medications, 13.8% had three medications and 17.6% had four medications. Of the patients whose dry eye symptoms were assessed using the OSDI questionnaire, 3.8% were normal, 15.7% were mild, 22.6% were moderate and 57.9% were severe dry eye. The mean OSDI score of all patients was 46.80 ± 19.44. The Schirmer test was found at less than 5 mm in 34.1% of eyes. In terms of TBUT, 52.3% of the eyes were evaluated as mild, 29.5% as moderate, 8.5% as severe. When evaluated for corneal staining, normal staining was observed in 13.2%, slight staining in 39.6%, moderate staining in 23.3% and severe staining in 23.9%. Conclusion: In diagnosing OCD, it would also be beneficial to use a test that includes not only the OSDI questionnaire but also tests showing the quality and stability of the tears.

Keywords:

Glaucoma, Antiglaucomatous agents, Ocular Surface Disease,

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