Migren ve periferik inflamasyon

Amaç: Migren inflamasyon ve vasküler hastalıklar ile ilişkili olabilen yaygın bir baş ağrısı türüdür. Biz genç erişkin migren hastalarında C-reaktif protein ve periferik kandaki bağışık hücre sayısını değerlendirdik.Hastalar ve Yöntem: Bu olgu-kontrol çalışması, 260 migren hastası (aurasız, 169 olgu, auralı, 91 olgu) ve 260 sağlıklı kontrol katılımcı (yaş aralığı, 18-50 yıl) olmak üzere 520 kişiyi içermektedir. Katılımcıların hiçbirinde bilinen bir anemi, vasküler risk faktörü veya inflamatuar hastalık yoktu. Migren ve kontrol olgularında serum C-reaktif protein ve tam kan sayımı parametrelerini değerlendirdik.Bulgular: C-reaktif protein, lökosit, nötrofil, lenfosit, trombosit sayıları ve ortalama trombosit hacmi migren hastalarında kontrol grubuna (P <0.001) oranla anlamlı olarak farklıydı. Ancak bu parametreler, C-reaktif protein hariç, auralı ve aurasız migrenlerde benzerdi. Lojistik regresyon analizinde migren hastalığı C-reaktif protein seviyesi (OR, 2.36; 95% CI, 1.73 ile 3.23; P< 0.001), ortalama trombosit hacmi (odds ratio [OR], 2.32; 95% confidence interval [CI], 1.78 - 3.0; P<0.001), ve lökosit sayısı (OR, 1.61; 95% CI, 1.32 - 1.94; P< 0.001) ile anlamlı olarak ilişkiliydi. Sonuç: Periferik inflamasyonun artmış seviyeleri migren hastalarında ortaya çıkabilir ve migren patogenezinde rol oynayabilir.

Anahtar Kelimeler:

Tam kan sayımı, C-reaktif protein, başağrısı, lökosit, lenfosit, trombosit

Migraine and peripheral inflammation

Aim: Migraine is a common headache disorder that may be associated with inflammation and vascular diseases. We evaluated C-reactive protein and the number of immune cells in the peripheral blood of young adult patients with migraine.Patients and Methods: This case–control study included 520 subjects: 260 patients with migraine (without aura, 169 patients; with aura, 91 patients) and 260 healthy control subjects (age range, 18–50 years). Participants had no known anemia, vascular risk factors, or inflammatory diseases. We evaluated serum C-reactive protein and complete blood count parameters in patients with migraine and control subjects.Results: C-reactive protein level, leukocyte, neutrophillymphocyte, platelet counts and mean platelet volume significantly differed in patients with migraine compared to controls (P<0.001). However, with the exception of C-reactive protein, these parameters were similar in migraine with and without aura. Logistic regression analysis showed that migraine was significantly associated with C-reactive protein level (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.73–3.23; P<0.001), MPV (OR, 2.32; 95% CI, 1.78–3.0; P<0.001), and leukocyte count (OR, 1.61; 95% CI, 1.32–1.94;). Conclusion: Increased levels of peripheral inflammation may occur in patients with migraine and may be involved in the pathogenesis of migraine.

Keywords:

Complete blood count, C-reactive protein, headache, leukocyte, lymphocyte, platelet,

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