Engin AYNACI, Birsen Pınar YILDIZ, Aysun AYNACI, Gönenç ORTAKÖYLÜ, Fırat ÇETİNKAYA, Emel ÇAĞLAR

Stabil Kronik Obstrüktif Akciğer Hastalığında İnflamatuar Belirteçler ve Hastalık Ağırlığı ile Karotis Arter İntima-Media Kalınlığının İlişkisi

Amaç: Çalışmamızda Kronik Obstrüktif Akciğer Hastalığı KOAH olgularında inflamatuar markerlar ve hastalığın şiddeti ile karotis arter intima-media kalınlaşması İMK arasında ilişki olup olmadığı araştırıldı.Gereç ve yöntem: Çalışmaya stabil durumda KOAH’ı olan 53 38erkek/15kadın hasta alındı. Hastaların yaş ortalaması 56,9±54 idi. Hastaların sağ ve sol karotis arterleri duplex scanner ile incelendi. Karotis İMK’nın ölçümleri; hastaların sigara içme alışkanlığı, KOAH’ın evresi, CRP ve fibrinojen seviyeleri, lökosit sayısı, BMİ ile karşılaştırıldı.Bulgular: Çalışmamızda KOAH evresi ile CRP düzeyi arasında anlamlı ilişki olduğu görüldü p=0.01 . Fakat İMK ile CRP de dahil olmak üzere diğer parametreler arasında ilişki saptanmadı.Sonuç: KOAH’lı hastalarda vasküler sistem üzerine sistemik inflamatuar hastalık olan KOAH’ın etkisini belirlemek üzere daha geniş çalışmalara ihtiyaç vardır

The Comparison of Carotid Artery Intima Media Thickness and Inflamatory Markers In Patients With Copd

Aim: The aim of the study was to evaluate the relationship between intimamedia thickness of carotid artery and inflammatory markers and severity of disease in patients with COPD. Materials and method: Fifty-three stable COPD patients 38males/15females with median age 56,9±54 years old were included. Right and left carotid arteries were examined with a duplex scanner. Intima-media thickness IMT measurements of the carotid artery are compared to levels of CRP, fibrinojen, leucocyte counts, BMI, and stage of the disease. Results: There is significant relationship between the stage of COPD and the levels of CRP elevation p=0.01 . But no relationship was found between intima media thickness and the parameters we have investigated, including CRP. Conclusion: There have to be made new extended studies, to examine the effects of COPD, as a systemic inflamatory disease, on vasculer system

Keywords:

Inflammation, Chronic obstructive lung disease, intima media thickness, Carotid artery,

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