Dilcan KOTAN, Lütfi ÖZEL, Hızır ULVİ, Recep AYGÜL

GENÇ İSKEMIK İNMEDE RİSK FAKTÖRÜ OLARAK PROTROMBİN GEN MUTASYONU: BİR OLGU SUNUMU

Genç inme, kırkbeş yaşın altında görülen inmelerdir ve inme insidansı 2,5 -40/100.000 arasında değişmektedir. Bütün inmelerin %4+-10 kadarı gençlerde görülür. Genç erişkindeki inmelerin çoğu iskemik orjinlidir. Genç iskemik inme nedenleri ileri yaşa oranla daha farklıdır ve altta yatan nedeni bulmaya yönelik pekçok araştırma yapmak gerekebilir. Bu araştırmalar serebral anjiyografi, transözefageyal ekokardiyografi, koagulasyon bozukluklarını tespit için testler ve kollajen vasküler hastalıkların araştırılması gibi tetkikleri içermektedir. Trombofili panelindeki protrombotik mutasyonlardan FV Leiden, MTHFR C677T ve Protrombin G20210A üzerinde şimdiye kadar daha yoğun çalışılmıştır. Burada, protrombotik gen heterozigot polimorfizimi tespit edilen genç iskemik inmeli bir kadın olgu sunulmaktadır

Prothrombin Gene Mutation As a Risk Factor In Young Ischemic Stroke: a Case Report

Stroke at young age is the stroke seen under the age of 45 years with the incidence range between 2.5 and 40/100.000. Stroke at young age is account for 4-10% of overall stroke cases. The majority of strokes in young adults are of ischemic origin. The causes of young ischemic strokes are different than those of advanced age and many analyses may be required to find out the underlying reason. These analyses include cerebral angiography, transesophageal echocardiography, tests to detect coagulation disorders, and investigation of collagen vascular diseases. Studies have most frequently focused on FV Leiden, MTHFR C677T and Prothrombin G20210A, which are among prothrombotic gene mutations in thrombophilia panel. Herein, a young female case with young ischemic stroke, in which heterozygote polymorphism of prothrombotic gene has been detected, was presented

Keywords:

young stroke, prothrombin gene mutation, pregnancy,

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