Edip Erdal YILMAZ, Ahmet TÜRKOĞLU, Ömer USLUKAYA, Sadullah GİRGİN

Warfarin Kullanımı Sonrası Gelişen İzole Sol Meme Hematomu

Tromboembolik olayların önlenmesinde yaygın olarak kullanılan warfarin en sık kullanılan oral antikoagülandır. Warfarin kullanımına bağlı diğer antikoagülanlarda olduğu gibi hemoraji ve hematom riski artmaktadır. Hematom daha çok ciltte, karında, sırtta ve bacaklarda oluşmaktadır. Memenin cildinde hemoraji ise oldukça nadir olarak gözlenmektedir. Memenin cildinde nekroza kadar ilerleyen hemoraji, dikkat edilmezse, mastektomi gibi ciddi sonuçlar doğurabilir. Bu konuya ilgi çekmek amacıyla Warfarin kullanımına bağlı tek bir memede areola çevresinde oluşan meme hematomlu vaka sunulmuştur.

Anahtar Kelimeler:

Warfarin, Hematom, Meme

Isolated Hematoma In The Left Breast Developing After Warfarin Use

Warfarin which is widely used for prevention of thromboembolic events is the most commonly used oral anticoagulant. Warfarin use increases the risk for hematoma as other anticoagulants. While hematoma is observed in other body parts, it is rare in the breast. It may result in skin necrosis and mastectomy unless attention. Herein, we presented a case who developed hematoma in the left breast and progression to skin lesion was prevented.

Keywords:

Warfarin, Hematoma, Breast,

PDF

___

1. Landefeld CS, Beyth RJ. Anticoagulantrelated bleeding: clinical epidemiology, prediction, and prevention. Am J Med 1993;95:315-28
2. Khalid K. Varfarin-induced necrosis of the breast. J Postgrad Med 2004;50:268-9.
3. Kahn S, Stern HD, Rhodes GA. Cutaneous and subcutaneous necrosis as a complication of Coumadin-congener therapy. Plast Reconstr Surg. 1971;48:160.
4. Fihn SD, Callahan CM, Martin DC, McDonell MB, Henikoff JG, White RH. The Risk for and Severity of Bleeding Complications in Elderly Patients Treated with Warfarin. Ann Intern Med 1996;124:970-9.
5. MacMahan DA, Smith DM, Carey MA, Zhou XH. Risk of Major Hemorrhage for Outpatients Treated with Warfarin. J Gen Intern Med 1998;13:311-6.
6. Van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briet E. Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med 1993;153:1557-62.4.
7. Makris M, Watson HG. The management of coumarin-induced overanticoagulation. Br J Haematol 2001;114:271-80.
8. Makris M, Greaves M, Phillips WS, Kitchen S, Rosendaal FR, Preston EF. Emergency Oral Anticoagulant Reversal: The Relative Efficacy of Infusions of Fresh Frozen Plasma and Clotting Factor Concentrate on Correction of the Coagulopathy. Thromb Haemost 1997;77:477-80
9. Taheri AR, Abdali H. Warfarin induced massive and bilateral skin necrosis of the breasts: a case report and review of the literature. Acta Med Iran.2005;43:303Y305.
10. Harveil JD, Furman RL. Recurrent Varfarin-induced soft tissue necrosis resulting in mastectomy. Mil Med. 1993;158:283-4.