Yeksin HELVACIOĞLU, Yasemin TAŞÇI, Rahime FINDIK BEDİR, Özlem ERYILMAZ GÜN, Jale KARAKAYA, Ebru ERSOY

Plasental Kalsifikasyonun Perinatal Sonuçlara Etkisi

Amaç: Plasental kalsifikasyon, gebelerde sıklıkla karşılaşılan ve klinik önemi bilinmeyen durumlardan biridir. Plasental kalsifikasyonun gebelikte risk faktörü olduğunu savunan yazarlar vardır. Çalışmamızda miad gebelerde plasental kalsifikasyonun perinatal sonuçlar açısından kliniğe yansıması değerlendirildi. Yöntem: Riski olmayan toplam 106 miad gebe çalışmamıza dahil edildi. Ultrasonografide grade 3 plasentası olan 51 gebeden oluşan vaka grubu ile, grade 1- 2 plasentası olan 55 gebeden oluşan kontrol grubu perinatal sonuçlar açısından karşılaştırıldı. Bulgular: Kalsifiye plasentası olan hastaların gebelik sayıları ve yaş ortalamaları diğer gruba göre anlamlı düşük bulundu sırasıyla p=0,003; p

Anahtar Kelimeler:

Plasental kalsifikasyon, perinatal sonuç, plasental ultrasonografi, riskli gebelik

The Effects of Placental Calcification on Perinatal Outcomes

Objective: Placental calcification is a commonly encountered situation with an unknown significance. There are publications defining the placental calcification as a risk factor in pregnant women. In our study, we overviewed the clinical reflection of placental calcification. Method: 106 patients without risk factors are included our study. The outcomes of 51 patients with grade 3 placental calcification on ultrasound were compared with 55 patients with grade 1-2 calcification. Results: Pregnancy counts and mean age were significantly lower in the study group with calcified placenta, compared to the group without calcification p=0,003; p

Keywords:

Placental calcification, perinatal outcomes, placental ultrasonography, high-risk pregnancies,

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1. Ergür AT, Berberoğlu M, Atasay B, Şıklar Z, Bilir P, Arsan S, Söylemez F, Öcal G.Vitamin D deficiency in Turkish mothers and their neonates and in women of reproductive age. J Clin Res Ped Endo 2009;1(6):266-9.
2. Hochberg Z, Bereket A, Davenport M, DelemarreVan de Waal HA, De Schepper J, Levine MA, Shaw N, Schoenau E, van Coeverden SC, Weisman Y, Zadik Z. Consensus development for the supplementation of vitamin D in childhood and adolescence. European Society for Paediatric Endocrinology (ESPE) Bone Club. Horm Res 2002;58(1):39-51.
3. Fraser DR.Vitamin D. Lancet 1995;345:104-7.
4. Cooley SM, Donnelly JC, Walsh T, McMahon C, Gillan J, Geary MP.The impact of ultrasonographic placental architecture on antenatal course, labor and delivery in a low-risk primigravid population.J Matern Fetal Neonatal Med 2011;24(3):493-7
5. Grannum PA, Berkowitz RL, Hobbins JC. The ultrasonic changes in the maturing placenta and their relation to fetal pulmonic maturity. Am J Obstet Gynecol 1979;133(8):915-22.
6. Miller JM, Brown HL, Kissling GA, Gabert HA The relationship of placental grade to fetal size and growth at term. Am J Perinatol. 1988;5(1):19-21.
7. Poggi SH, Bostrom KI, Demer LL, Skinner HC, Koos BJ. Placental calcification: a metastatic process? Placenta. 2001;22(6):591-6.
8. Vosmar MB, Jongsma HW, van Dongen PW. The value of ultrasonic placental grading: no correlation with intrauterine growth retardation or with maternal smoking.J Perinat Med. 1989;17(2):137- 43.
9. Chen KH, Chen LR, Lee YH. Exploring the relationship between preterm placental calcification and adverse maternal and fetal outcome.Ultrasound Obstet Gynecol. 2011;37(3):328-34
10. McKenna D, Tharmaratnam S, Mahsud S, Dornan J.Ultrasonic evidence of placental calcification at 36 weeks' gestation: maternal and fetal outcomes.Acta Obstet Gynecol Scand. 2005;84(1):7-10.
11. Nolan RL, Brennan J, Coyne KP, Spong S, Spar J, Strauss N, Milan T, Speight D, Tedlow RS, Gillotti D, Yardeni E, Block DJ, Radin SA, Sheinheit S, Robbins B. Connectivity and control in the year 2000 and beyond.Harv Bus Rev. 1998;76(4):148-55, 156-62, 164-6.
12. Spirt BA, Cohen WN, Weinstein HM. The incidence of placental calcification in normal pregnancies. Radiology. 1982;142(3):707-11.
13.Proud J, Grant AM. Third trimester placental grading by ultrasonography as a test of fetal wellbeing. Br Med J (Clin Res Ed). 1987;27:294(6588):1641-4.
14.Chitlange SM, Hazari KT, Joshi JV, Shah RK, Mehta AC. Ultrasonographically observed preterm grade III placenta and perinatal outcome.Int J Gynaecol Obstet. 1990;31(4):325-8.
15. Hills D, Irwin GA, Tuck S, Baim R. Distribution of placental grade in high-risk gravidas.AJR Am J Roentgenol. 1984;143(5):1011-3.
16. Quinlan RW, Cruz AC, Buhi WC, Martin M.Changes in placental ultrasonic appearance. I. Incidence of Grade III changes in the placenta in correlation to fetal pulmonary maturity.Am J Obstet Gynecol. 1982:15;144(4):468-70.
17. Hill LM, Breckle R, Ragozzino MW, Wolfgram KR, O'Brien PC Grade 3 placentation: incidence and neonatal outcome. Obstet Gynecol. 1983;61(6):728- 32.
18. Jeacock MK .Calcium Content of Human Placenta.Am J Obstet Gynecol. 1963:1;87:34-40
19. Altuğ M, Tuna T, Küpelioğlu D, Kasabalıgil A, Bozkurt S. Amniyotik Sıvı Volümü, Plasental Grade ve Plasental Morfolojik Değişikliklerin Fetal Prognoz Açısından Değerlendirilmesi. Perinatoloji Dergisi. 1994:2:112-115.
20. Cooley SM, Donnelly JC, Walsh T, McMahon C, Gillan J, Geary MP. The correlation of ultrasonographic placental architecture with placental histology in the low-risk primigravid population. J Perinat Med. 2013: 1;41(5):505-9.