Mehmet Rami HELVACI, Asena Çiğdem DOĞRAMACI, Özlem EKİZ, Bilge BÜLBÜL ŞEN, Emine Nur RİFALOĞLU, Mehmet YALDIZ

Multipl myelomda deri tutulumu: bir olgu sunumu

Multipl myelom MM kemik iliğinden köken alan ve monoklonal immunglobulin üreten plazma hücreleri ile karakterize hematolojik bir malinignitedir. MM’li hastalarda deri tutulumu çok nadir görülmektedir. Yetmiş üç yaşında, IgG lambda MM tanısı olan hasta deri lezyonları nedeniyle Dahiliye bölümü tarafından bölümümüze konsülte edildi. Yapılan dermatolojik muayenede üst ekstremitelerde, gövde ön ve arka yüzde dağınık yerleşimli, çapları 2-5 cm arasında değişen, eritemli viyolase renkte toplam 10 adet tümöral lezyon izlendi. Lezyonlardan alınan biyopsinin histopatolojik incelemesinde lambda monoklonaliteli diffüz atipik plazma hücre infiltrasyonu saptanması nedeniyle hastanın lezyonları MM deri tutulumu olarak değerlendirildi.

Anahtar Kelimeler:

Deri tutulumu, metastaz, multipl myelom

Cutaneous involvement in multiple myeloma: a case report

Multiple myeloma MM is a hematological malignity that originates from the bone marrow and is characterized by plasma cells that produce monoclonal immunoglobulin. Cutaneous involvement is very rare in patients with MM. A 73-year-old, male patient, who has a diagnosis of IgG lambda MM, was referred to our clinic from the Department of Internal Medicine due to his skin lesions. The dermatological examination revealed a total of 10 erythematous violaceous-tumoral lesions with a diameter varying between 2-5 cm, on upper extremities, the front and back of the body. The lesions of the patient were considered as cutaneous involvement of MM because histopathological examination of skin biopsy is showed diffuse atypical plasma cell infiltration with lambda monoclonality.

Keywords:

Skin involvement, metastasis, multiple myeloma,

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