Eyüp BÜYÜKKAYA, Şule BÜYÜKKAYA, Adnan Burak AKÇAY, Mehmet Fatih KARAKAŞ, Esra KARAKAŞ, Mustafa KURT, Nihat ŞEN

Kardiyak sendrom X'de eritrosit dağılım genişliği (R DW) ile Hs-CRP seviyelerinin incelenmesi

Amaç: Kardiyak Sendrom X(KSX), angina pektoris ve objektifiskemi bulgularına rağmen normal koroner arterlerin saptandığı bir tablodur. KSX in patogenezinde inflamasyonunrol oynadığı bulunmuştur. Eritrosit dağılım genişliği (RDW),dolaşımdaki eritrositlerin büyüklüğünü gösteren bir indeksolmasının yanında, son çalışmalarda inflamasyonu gösterenbir parametre olarak değerlendirilmeye başlanmıştır. Biz buçalışmada KSX olan hastalarda inflamasyon ile RDW arasındaki ilişkiyi araştırdık.Yöntem: Bu çalışmaya iskemik bulguların saptandığı koroneranjiyografisi normal olan 35 KSX hastası (KSX grubu), ciddikoroner arter hastalığı bulunan 35 hasta (KAH grubu) ve 34kontrol hastası alındı. Her üç gruptan RDW ve hs -CRP çalışıldı .Bulgular : KSX grubunda RDW değerleri kontrol grubuna göreartmış bulundu (13.9 ± 1.2 vs 12.9 ±0.7, p < 0.001). AncakKSX grubu ile KAH grubu arasında fark bulunmadı (13.9 ± 1.2vs. 14,1 ± 1,1, p: 0. 63). Aynı şekilde KSX ile KAH grubu arasında hs-CRP değerleri arasında fark yoktu(1.03 ± 0.5 vs. 1.05± 0.5, p: 0.92). Kontrol grubu nda hs-CRP düzeyi KSX ve KAHgrubuna göre anlamlı bir şeki l de düşük bulundu. RDW ile hs- CRP arasında pozitif korelasyon olduğu bulu n du(r=0.24, p:0.014).Sonuç : RDW, klinikte uzun süredir bilinen ancak inflamatuvar marker olarak yeni kullanılan bir parametre olup KSXolan hasta larda yükselmektedir.

Association between red cell distribution width (R DW) and Hs-CRP in patients w ith cardiac syndrome X

Objective : Cardiac Syndrome X (CSX) is defined as typicalchest pain, objective signs of ischemia and normal coronaryarteries. The association between CSX and inflammation iswell known. Red cell distribution width (RDW), an index oferythrocyte size, is recently found to be associated withinflammation. We investigated the association betweenRDW and high sensitive C reactive protein (hs-CRP) in patients with CSX.Method : Total 104 patients were included in the study.Those with evidence of ischemia (total of 70) underwentcoronary angiography. Patients with a normal coronaryangiogram were grouped as the CSX group (n=35 )and thosewith significant coronary disease were grouped as the coro-nary artery disease(CAD) group(n=35). A total of 34 patientswere taken as the control group. RDW and hs-CRP levelswere measured. Results : RDW was increased in the CSX group when compared to the Control group (13.9 ± 1.2 vs 12.9 ±0.7, p

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