Endometrial Polip Tanısı Konulan Olgularda Ghrelin'in Serum ve Doku Düzeyi Seviyelerinin Araştırılması

Amaç: Endometrial polipler infertiliteye neden olabilen endometriumun iyi huylu lezyonlarıdır. Bu çalışmada ghrelin miktarının endometrial polip gelişimindeki etkisi değerlendirildi. Materyal ve metod: Endometrial polip tanısı konulan 9'u proliferasyon, 6'sı sekretuvar fazda 15 olgunun doku ghrelin miktarı immünohistokimyasal metod, Enzim İmmunoassay (EIA) ve ELİSA ile değerlendirildi. Bulgular: Ghrelin konsantrasyonu sekretuvar fazda proliferatif faza göre daha yüksekti. Ghrelin konsantrasyonu endometrial polipte endometrium grubuna göre daha düşüktü. Sonuç: Endometrial polip oluşumunda ghrelin salınımı önemli bir rol oynamaktadır.

Anahtar Kelimeler:

Ghrelin, Endometriyum, Polip

Investigation of Plasma and Tissue Ghrelin Levels in Diagnosed Endometrial Polyps

Background: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. We aimed to evaluate the ghrelin expressions for the development of endometrial polyps. Methods: Tissue ghrelin expressions of a total of 15 cases endometrial polyps, whom 9 had in the proliferation phase, 6 had in the sekretuar phase were examined using immunohistochemical method, Enzim İmmunoassay (EIA) and ELİSA. Results: Ghrelin concentrations in the secretuar phase group were higher compared to the proliferative phase. Ghrelin concentrations were lower in the endometrial polyps group as compared to the endometrium group in the secretuar phase. Conclusions: We think that ghrelin expression can be important in endometrial polyps formation.

Keywords:

Ghrelin, Endometrium, Polyp,

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