Gözde KIR, Handan ÇETİNER, Ateş KARATEKE, Fatih DURMUŞOĞLU

Serviksin papiller immatür metaplazisinin sitolojik ve histolojik bulguları, 2 olgu sunumu

Serviksin papiller ve nonpapiller atipik İmmatür metaplastik proliferasyonları son zamanlarda tanımlanmıştır. Papiller İmmatür metaplazinin kriterleri net olarak tanımlanmış olup, değişik matürasyon aşamasında skuamöz metaplastik epitel, küçük veya filiform papiller yapılar ve sitolojik atipi ile karekterizedir. Birinin smearı pozitif olmak üzere, histopatolojik incelemede papiller İmmatür metaplazi tanısı almış iki olguyu literatür bulguları eşliğinde tartıştık ve papiller immature metaplazi, "low grade squamous intraepithelial lesion", "high grade squamous intraepitheliallesion", skuamöz metaplazi ve matür skuamöz epitelin Ki- 67 ile boyanma özelliklerini karşılaştırdık.

Anahtar Kelimeler:

Metaplazi, Serviks uteri

Papillary immature metaplasia of the cervix, cytologic and histologic findings

Some immature squamous lesions of the cervix (papillary and nonpapillary atypical immature squamous proliferations) have been described recently. Papillary immature metaplasia have been well defined. It's characterized by a metaplastic growth pattern of variable maturation,the presence of papillary architecture ranging from small papilla to slender projections, lining cells exhibiting variable cytologic atypia . Our two patients diagnosed as papillary immature metaplasia have been discussed with literature findings. We compared expression of Ki- 67 between papillary immature metaplasia, low grade squamous intraepithelial lesion, high grade squamous intraepithelial lesion, squamous metaplasia and mature squamous epithelium.

Keywords:

Metaplasia, Cervix Uteri,

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1- Park JJ, Genest DR, Sun D, Crum CP : Atypical Immature Metaplastic- like Proliferations of the Cervix: Diagnostic Reproducibility and Viral (HPV) Correlates. Hum Pathol 1999; 30 : 1161-65
2- Gong L, Connolly DC, Isocson C, Ronnett BM, Cho KR : Atypical Immature Metaplasia (AIM) of the Cervix : Is It Related to High-Grade Squamous Intraepithelial Lesion (HSIL) ? Hum Pathol 1999; 30 : 345-51
3- Trivijitsilp P, Mosher RE, Sheets EE, Sun D, Crum CP : Papillary Immature Metaplasia (Immature Condyloma) of the Cervix : A Clinicopathologic Analysis and Comparision With Papillary Squamous Carcinoma. Hum Pathol 1998; 29: 641- 48
4- Sternberg SS. Diagnostic Surgical Pathology, Chapter 52. Third ed Philadelphia, Lippincott Williams & Wilkins, 1999; pp : 2161-63
5- Word BE,Saleh AM, Williams JV, Zitzf C, Crum CP: Papillary immature Metaplasia of the Cervix : a distinct subset of exophytic cervical condyloma associated with HPV-6/11. Mod Pathol 1992 ; 5 (4) : 391-95
6- Mosher RE, Lee KR, Trivijitsilp P, Crum CD : Cytologic Correlates of Papillary Immature Metaplasia (Immature Condyloma) of the Cervix
Diagn Cytopathol 1998 ; 18: 416-21
7- Duggan MA: Cytologic and histologic diagnosis and signifigance of controversial squamous lesions of the cervix. Mod Pathol 2000 ; 13 (3) : 252-60
8- Mittal K: Correspondence : Atypical Immature Metaplastic-like Proliferations of the Cervix. Hum Pathol 2000 ; 31: 1179-80
9- Mittal K, Palazzo J: Correspondence :Atypical Immature Metaplasia of Cervix. Hum Pathol 1999 ; 30:996-97