Barış MÜLAYİM, Nülüfer Y. ÇELİK, Sema MÜLAYİM

Primer amenore: Olgu serileri

Primer amenore, üreme çağındaki kadınların %0.1 ile %2.5'nda görülmektedir. Başlıca nedenleri gonadal yetmezlik (%48.5), uterus ve vajinanın konjenital yokluğu (%16.2) ve konstitüsyonel gecikme (% 0.5) 'dir. Adet göremeyen hastaların, hikayesi ve fizik muayenesi çok önemlidir ve bunun yanında TSH, prolaktin, FSH, LH ve estradiol hormon seviyeleri ve karyotip analizi de gerekebilir. Ultrason (US) ve magnetik rezonans görüntüleme (MRG), görüntüleme yöntemleri arasındadır. Eğer klinik ve US veya MRG arasında farklılıklar var ise tanıyı konfirme etmek için laparoskopi yapılabilir. Burada primer amenore ile polikliniğimize başvuran 3 olguyu sunmak istedik. Bu olgulara yukarıda vurguladığımız yöntemler sayesinde Turner sendromu (TS), Mayer Rokitansky Küs ter Hauser sendromu (MRKH) ve hipogonadotropik hipogonadizm ?(HH) tanıları konmuştur.

Anahtar Kelimeler:

Amenore, Turner sendromu, Genç erişkin, Kadın, Hipogonadizm

Primer amenore: Olgu serileri

Primary amenorrhea occurs in 0.1% to %2.5% of women in the reproductive age group. Gonadal deficiency (%48.5), congenital agenesis of uterus and vagina (%16.2) and constitutional delay (% 0.5) are the major reasons. Medical history and physical examination are very important in patients who are amenorrheic and besides TSH, prolactin, FSH, LH and estradiol hormone levels and karyotype analysis also may be needed. Ultrasound (US) and magnetic resonans imaging (MRI) are among the imaging procedures. If there is discrepancies between clinical signs and US or MRI findings, laparoscopy can be performed for confirmation of diagnosis. Here, we would like to report 3 cases who were admitted to our outpatient clinic with primary amenorrhea. Those cases were diagnosed as Turner syndrome (TS), Mayer Rokitansky Küster Hauser syndrome (MRKH) and hipogonadotropic hipogonadism (HH) thanks to the methods we have mentioned above.

Keywords:

Amenorrhea, Turner Syndrome, Young Adult, Female, Hypogonadism,

PDF

___

1. Timmreck LS, Reindollar RH. Contemporary issues in primary amenorrhea. Obstet Gynecol Clin North Am 2003; 30:287-302
2. Pletcher JR, Slap GB. Menstruel disorders
Amenorrhea. Pediatr Clin North Am 1999; 46:505-518
3. Balcı MK. Amenore. Türkiye Klinikleri Endokrinoloji Dergisi. 2003,-1:107-113
4. Leon Speroff and Marc A. Fritz. Clinical Gynecologic Endocrinology and Infertility. Normal and Abnormal Sexual Development. 7. Baskı, Philadelphia: Lippincott Williams and Wilkins, 2005:319-361
5. Leon Speroff and Marc A. Fritz. Clinical Gynecologic Endocrinology and Infertility
Amenorrhea. 7. Bash, Philadelphia: Lippincott Williams and Wilkins, 2005:401-465
6. Bridges NA, Cooke A, Healy MJ, Hindmarsh PC, Brook CG. Growth of the uterus. Arch Dis Child 1996; 75:330-331
7. OrbakZ, Sagsoz N, Alp H, Tan H, Yildirim H, Kaya D. Pelvic ultrasound measurements in normal girls: relation to puberty and sex hormone concentration. J Pediatr Endocrinol Metab 1998; 11:525-530
8. Tsilchorozidou T, Conway GS. Uterus size and ovarian morphology in women with isolated growth hormone deficiency, hypogonadotrophic hypogonadism and hypopituitarism. Clin Endocrinol (Oxf) 2004; 61:567-572
9. Saatçi Ç, Özkul Y, Müderris İİ, ve ark. . Turkiye Klinikleri Jinekoloji ObstetrikDergisi 2008; 18:83-88 10. Mueller GC, Hussain HK, Smith YR. et al. Müllerian duct anomalies: comparison of MRI diagnosis and clinical diagnosis. 2007; 189:1294-