Deniz KÖSE, Hüsamettin USLU, Akın VARLIK, Arzu AYDIN, Akif ALKAN

Preterm doğum eyleminde maternal serum AFP ve hCG düzeyleri

Amaç: Üçüncü trimester serum AFP ve hCG düzeyleri ile preternı eylem arasındaki ilişkiyi araştırmak. Materyal ve Metod: Ağustos 2002 - Mayıs 2003 tarihleri arasında Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi'ne başvuran 27-33 gebelik haftasındaki 100 gebe çalışmaya dahil edildi. Olguların 51 tanesi preterm eylemde iken 49 tanesi kontrol grubu olarak alınmıştır.Olgular yaş, parite, gebelik haftası, maternal serum AFP ve hCG parametreleri açısından karşılaştırıldı. Bulgular: Preterm eylemdeki gebelerde maternal yaş kontrol grubuna göre anlamlı olarak düşük bulunurken(p — 0,03), gebelik haftası ve parite açısından anlamlı fark izlenmedi. Preterm eylem grubu ve kontrol grubunda maternal serum AFP ve hCG arasında anlamlı bir farklılık saptanmadı (p = 0,06vep = 0,170). Sonuç: Üçüncü trimester maternal serum AFP ve hCG düzeylerinin preterm eylem riskinin öngörüsünde değerli olmadığı ve bu dönemin, riski belirlemek için geç bir dönem olduğu kanısına vardık.

Anahtar Kelimeler:

Prematüre doğum, Koryonik gonadotropin, alfa-Fetoproteinler, Gebelik trimesterleri

Maternal serum AFP and hCG levels in preterm labor

Objective: To evaluate the relationship between preterm labor and third trimester maternal serum AFP, hCG levels. Materials and Methods: One hundred women who were 27-33 weeks pregnant were enrolled to this study between August 2002 - May 2003 at Zeynep Kamil Women and Children Research and Training Hospital. Fiftyone pregnant women who had the diagnosis of preterm labor were included in the study group and 49 healthy pregnants encompassed the control group. Maternal serum AFP, hCG, maternal age, parity and gestational week were analysed. Results: Maternal age was significantly lower in the preterm labor group compared to the control group(p=0.03) while parity and gestational week were statistically indifferent. Maternal serum AFP and hCG levels had shown no significant difference when compared between two groups (p=0.06 andp=0.170). Conclusions: Third trimester should be considered late in predicting the risk of preterm labor and we have found no relationship between the levels of maternal AFP, hCG and preterm labor in the third , trimester.

Keywords:

Premature Birth, Chorionic Gonadotropin, alpha-Fetoproteins, Pregnancy Trimesters,

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