Postmenopozal smearlerin servikal intraepiteliyal neoplazi yönünden değerlendirilmesi
Amaç: Bölgemizdeki postmenopozal kadınlardaki CİNprevelansını göstermek amacıyla bir çalışma düzenledik. Materyal ve Metod: 1997 ve 2000 yıllan arasında menopoz polikliniğine HRT almak üzere başvuran 12783 hastapatoloji kayıtları incelenerek retrospektif olarak değerlendirilmiştir. Bulgular: 349 hastada anormal smear sonucu saptanmış olup bunların 265'i (%75.8) CİNİ, 4O'ı (%11.4) CİN II, 6 tanesi CİN III ( %2 ), 2 tanesi karsinoma insitu (% 0.6) ve 36 tanesi koilositozisdir (% 10.2 ) Bu yaş grubunda anormal servikal sitoloji genel prevelansı ise yaklaşık olarak %3 olarak belirlenmiştir. Sonuç: Postmenopozal dönemde erken dönem servikal intraepiteliyal lezyonlarm hiç de azımsanmayacak boyutlarda olması nedeniyle asemptomatik de olsa postmenopozal hastaların transformasyon zonu açısından değerlendirilmesi gerekliliği oldukça açıktır.
Evaluation of postmenopausal smears with regard to cervical intraepithelial neoplasia
Objective: To investigate the prevelance of CIN in postmenopausal women in our region. Material and Methods: Between 1997 and 2000 years, 12783 women who applied Menopause Clinic for taking hormone replacement therapy with or without complaints were retrospectively evaluated. Results: Of the 349 cases with abnormal smear findings, 265 were CIN I (%75.8 ), 40 were CIN II (%11.4 ), 6 were CIN III (%2), 2 were carsinoma insituf %0.6 )and 36 were koilocytosis (%10.2 ). General prevelance of abnormal cervical findings in this age group was determined aproximately % 3. Conclusios: Although in women of postmenopausal age early stage servical intraepithelial lesions is seen not rare, it is clearly that they must be evaluated for transformation zone even if they are asymptomatic.
___
- 1. Disaia Creasman, Clinical gynecologic
oncology. Sixth edition. 2002;1-4
2. Sebbelov AM, Kjorstad KE, Abeler VM, Norrild
B. The prevalence of HPV type 16 and 18 DNA
cervical cancer in different age groups: a study
on the incidental cases of cervical cancer in Norway
in 1983. gynecol Oncol. 1991:41:141-148
- 3. Schneider A, Koutsky LA. Natural history and
epidemiological features of genital HPV infection.In:
Munoz N,Bosh FX,Shah KV, Meheus A,eds. The
epidemiology of cervical cancer dnd human
papillomavirus. Lyon: International Agency for
Cancer Research, 1992;25-52
- 4. Mandelblatt J, Schecter C, Fahs M, Muller C
- Clinical implications of screening for cervical
cancer under Medicare. The natural history of
cervical cancer in the elderly: what do we know?
What do we need to know? Am J Obstet Gynecol
- 1991;164: 644-651
- 5. Meijer CJL'M, van de Brule AJC, Snijders PJF,
Helmefhorsi T, Kenemans P, Walboomers JMM
- Detection of human papillomavirus in cervical
scrapes by the polimerase chain reaction in relation to cytology: possible implications for cervical cancer screening. In: Munoz N, Bosh FX, Shsh KV, Meheus A, eds. The epidemiology of cervical cancer and human papillomavirus. Lyon: International Agency for Cancer Research. 1992;271-281
- 6. Walton RI, Blanchet M, Boves DA et al. Cervical
cancer screening programs. Can Med Assoc J. 1976;
114:1003-33
- 7. Roberts AD, Denholm RB, CordinerJW. Cervical
intraepithelial neoplasia in postmenopausal women
with negative cervical cytology. Br Med J. 1985; 290:281
- 8. Barron BA, Richard RM. Statistical model of the
natural history of cervical carcinoma: estimate of
the transition time from dyplasia to carcinoma
insitu. J Natl Cancer Inst 1970; 45: 1025-30
- 9. Gerbaldo D, Cristoforoni P, Leone M, Casciaro
L, Baracchini P, Fulcheri E. The incidental finding
of abnormal cervical histology in postmenopausal
patients. Maturitas. 1995; 21:115-120