Nevra DURSUN, MELTEM ÖZNUR, Cem LEBLEBİCİ, Tuğçe Güzel ÇAY, İNAN İLKER ARIKAN, H.Serpil BOZKURT, Fadime BAHADIR

Normal, hiperplastik ve kanserli endometriumda galektin-3, östrojen, progesteron ekspresyonu ve FIGO evre ile ilişkisi

Endometrium karsinomu gelişmiş ülkelerde jinekolojik kanserler içinde en sık görülenidir. Endometrium karsinomlarındaki hormon reseptör ekspresyonu, yerleşmiş prognostik faktörler arasında yer almaya başlamıştır. Galektin-3, _- galaktozid bağlayan lektin ailesinin bir üyesidir; bazal membran glikoproteinlerine bağlanarak pek çok biyolojik olayda rol oynadığı düşünülmektedir. Tümör progresyonunda galektin-3' ün rolü tam olarak bilinmemektedir. Çalışmamızda normal fonksiyonel (n=12), hiperplastik (atipili ve atipisiz) (n=7) ve kanserli (n=25) endometrial dokuda östrojen, progesteron ve galektin-3 ekspresyonunu ayrıca kanserli olgularda, ekspresy onların FIGO Evre'si ile ilişkisini immunhistokimyasal yöntemle inceledik. Normal endometrial dokudaki östrojenprogesteron ekspresyonu kanserli dokulara göre ileri derecede anlamlı saptandı(p

Anahtar Kelimeler:

Endometriyum, Galektin 3, Östrojenler, Progesteron, İmmünohistokimya, Histerektomi, Adenokarsinom, Karma tümör, mezodermal, Endometriyum neoplazmları

The relationship of gallectin-3, estrogen and progesteron expression and FIGO staging in normal, hyperplastic and carcinomatous endometrium

The Relationship Of Galectin-3, Estrogen And Progesteron Expression And FIGO Staging In Normal, Hyperplastic And Carcinomatous Endometrium Endometrium carcinoma is the most common gynecological malignancy in developed countries. Hormone receptor expression in endometrium carcinoma is one of the prognostic factors. It is thought that galectin-3, one of the member ofbetagalactozide- binding lectin family, binds to basal membrane glycoprotein and has a role in many biological events. Galectin-3's role in tumor progression is not completely understood. In our study, we examined estrogen, progesteron, and galectin-3 expression in normal functional (n=I2), hyperplastic (with or without atypia) (n=7), carcinomatous endometrial tissues (n-25) and also examined immunohistochemically the relationship of expression with FIGO staging. Estrogen, progesteron expressionin normal cases was more meaningful statistically than the one in carcinoma cases. (p

Keywords:

Endometrium, Galectin 3, Estrogens, Progesterone, Immunohistochemistry, Hysterectomy, Adenocarcinoma, Mixed Tumor, Mesodermal, Endometrial Neoplasms,

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