Kenan SOFUOĞLU, M. Nuri DELİKARA, Selçuk ÖZDEN, Gazi YILDIRIM, Toygun BAŞARAN, Mehmet GÜÇLÜ

IVF-ET sikluslarında ovaryen stimulasyon için rekombinant folikül stimulan hormon ve human menopozal gonadotropin kullanımının sonuçlar üzerine etkisi

Amaç: Ovulasyon indüksiyonu yapılan IVF-ET olgularında rekombinant folikul stimulant hormon (rFSH) ve human menopozal gonadotropin (hMG) kullanımının in-vitro fertilizasyon sonuçları üzerine etkisinin araştırılması. Materyal ve Metod: Nisan 2001-Mayıs 2002 tarihleri arasında Tüp Bebek Ünitesinde ovulasyon indüksiyonu yapılan kadınların dosyalarının retrospektif olarak incelenmesi ile hMG kullanılan 72 ve rFSH kullanılan 100 olgu analiz edilmiştir. Bulgular: Embryo transferi yapılan sikluslarda, gebelik oranlan hMG grubunda % 27.3 ve rFSH grubunda % 20.2 olarak saptanmıştır. Bu fark istatistik! olarak anlamlı değildir( p=0.35) hMG ve rFSH arasında elde edilen matür oosit, indüksiyon süresi, kullanılan total gonadotropin dozu ve fertilizasyon oranları ile ilişkili olarak hiçbir istatistiki anlamlı fark bulunmamıştır. Sonuç: Klinik gebelik oranları açısından her iki stimulasyon rejimi arasında anlamlı fark bulunmadığı saptandı.

Anahtar Kelimeler:

İnvitro fertilizasyon, Geriyedönük çalışma, Folikül uyarıcı hormon, Menotropinler, Ovülasyon uyarılması

Recombinant FSH versus human menopausal gonadotropins for ovarian stimulation in IVF cycles: Analysis of outcomes

Objective: To analyze the results of using rFSH and hMG for ovarian stimulation in in vitro fertilization cycles. Material and method: A retrospective analysis of all the treatment cycles between April 2001 and May 2002 were performed. Treatment with hMG was used for 72 patients, whereas 100 patients were treated with rFSH. Results: Of the cycles with embryo transfer, the pregnancy rates were 27.3 % and 20.2 % in the hMGand the rFSH groups, respectively. This difference is not statistically significant (p=0.35). No significant differences were found with regard to the number of mature oocytes, the duration of stimulation, the total amount of gonadotropin used and the fertilization rates. Conclusion: It's found that there was no significant difference between two stimulation regiments in terms of the clinical pregnancy rate.

Keywords:

Fertilization in Vitro, Retrospective Studies, Follicle Stimulating Hormone, Menotropins, Ovulation Induction,

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