Gözde KIR, Handan ÇETİNER, Sadiye EREN, Ayşe GÜRBÜZ

Endometrial intraepitelyal karsinomun eşlik ettiği uterin seröz papiller karsinom

Çalışmamızda 67 yaşında kadm hastada saptanan fokal intraepitelyal karsinom ile birlikte görülen uterin seröz papiller karsinom olgusu sunulmuştur. Uterin seröz papiller karsinomlûrın öncül lezyonu olarak ileri sürülen endometrial intraepitelyal karsinomlann özellikle küretaj materyallerinde tanınması önemlidir. Çalışmamızın amacı intraepitelyal karsinomlann morfolojik ve immunhistokimyasal özelliklerini irdelemektir.

Anahtar Kelimeler:

İn situ karsinom, Karsinom, papiller, Endometriyum, Endometriyum neoplazmları

Endometrial intraepithelial carcinoma associated with uterin serous papillary carcinoma

In our study, the case with focal intraepithelial carcinoma associated with uterin serous papillary carcinoma in a 67 year old woman was presented. Because of endometrial intraepithelial carcinoma has been proposed a procursor of uterin serous papillary carcinoma it is important to recognize it especially in curettage specimen. Aim of our study was to analyse morphologic and immunhistochemical features of endometrial intraepithelial carcinoma.

Keywords:

Carcinoma in Situ, Carcinoma, Papillary, Endometrium, Endometrial Neoplasms,

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1.Wheeler DT, Bell KA, Kurman RJ, Sherman ME
Minimal uterine serous carcinoma. Diagnosis and clinicopathologic correlation. Am J Surg Pathol 2000; 24: 797-806
2.McCluggage WG, Sumathl VP, McManus DT
Uterine serous carcinoma and endometrial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases including 2 associated with tamoxifen therapy. Hum Pathol 2003; 34: 939-43
3.Soslow RA, Pirog E, Isacson C. Endometrial intraepithelial carcinoma with associated peritoneal carcinomatosis. Am J Surg Pathol 2000; 24: 726-32
4-Ambros RA, Sherman ME, Zahn CM, Bitterman P, Kurman RJ. Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol 1995, 26: 1260-7
5.Baergen RN, Warren CD, Isacson C, Elenson LH
Early uterine serous carcinoma: clonal origin of extrauterine disaese. IntJ Gynecol Pathol 2001; 20: 214-9
6.Zhang W, Khurana R, Farahmend S et al. P 53 immunstaining as a significant adjunt diagnostic method for uterine surface carcinoma. Am J Surg Pathol 1998; 22: 1468-78
7.Coranado PJ, Fasero M, Vidart JA, Puerto J, Magrina J, Furio-Bacete V, Ascudero M
A comparison of epithelial membrane antigen overexpression in benign and malignant endometrium. Gynecol Oncol 2001; 82: 483-88
8.Nakopoulou L, Minaertzis D, Tsionou CH, Mastrominas M. Value of immunohistochemical demonstration of several epithelial markers in hyperplastic and neopalstic endometrium. Gynecol Oncol 1990; 37: 346-53
9.Morse AR, Curran GJ. Distribution of epithelial membrane antigen in normal and abnormal endometrium tissue. Br J Obstet Gynaecol 1985; 92: 1286-90.