Comparison of the Levonorgestrel-Releasing Intrauterine Systemand Oral Tranexamic Acid in the Treatment of Dysfunctional Uterine Bleeding

Objective: To compare LNG-IUS and oral tranexamic acid in dis-functional uterine bleeding (DUB) therapy in terms of efficacy in reducing blood loss during menstruation, side effects, and comp-liance with therapy.Material and Methods: 60 patients who were diagnosed with DUB and were treated with either oral tranexamic acid 3gr/day or LNG-IUS were included in the study. Bleeding scores (PBAS), duration of bleeding and haemoglobin values before the therapy were recorded. Patients were evaluated again for the same pa-rameters and possible side effects on the 3rd and 6th months of therapy.Results: Decrease in duration of bleeding on the 3rd and 6th months of therapy were statistically significant in both groups (p0,05), the decrease was more significant in the LNG-IUS group than the tranexamic acid group on the 6th month (p0,05). In the LNG-IUS group, PBAS decreased by 87.5 % on the 3rd month, and 90.5% on the 6th month, and these changes were statistically significant (p

Disfonksiyonel Uterin Kanama Tedavisinde Levonorgestrel Salgılayan İntrauterin Sistemve Oral Traneksamik Asit Etkinliğinin Karşılaştırılması

Amaç: Disfonksiyonel uterin kanama (DUK) tedavisinde LNG-I-US (Levonergestrel salgılayan intrauterin sistem) ve oral tranek-samik asit menstrüel kan kaybını azaltmadaki etkinliği, yan etkiler ve tedaviye devam açısından karşılaştırılmıştır.Gereç ve Yöntemler: Çalışmaya DUK tanısı alıp LNG-IUS uygu-lanan ve 3 gr/gün oral traneksamik asit kullanan toplam 60 hasta dahil edildi. Hastaların gözlemsel kanama skorlama sistemi ile hesaplanmış tedavi öncesi kanama skorları (PBAS), kanamalı gün sayıları ve hemoglobin değerleri kaydedildi. Hastalar tedavinin 3 ve 6. aylarında çağrılarak kanama skorları (PBAS), kanamalı gün sayıları, hemoglobin değerleri kaydedilip, yan etkiler açısından ayrıntılı sorgulandı.Bulgular: İki gruptada 3 ve 6. ayda kanamalı gün sayısındaki azalma istatiksel olarak anlamlıdır (p0,05), 6. ayda LNG-IUS grubunda-ki azalma traneksamik asit grubundaki azalmadan daha fazladır (p0,05). LNG-IUS grubunda PBAS’de 3. ayda %87,5 ve 6. ayda %90,5 azalma olup, 6. aydaki azalma istatiksel olarak daha fazladır (p

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Zeynep Kamil Tıp Bülteni-Cover
  • ISSN: 1300-7971
  • Başlangıç: 1969
  • Yayıncı: Ali Cangül
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