Özlem ARSLAN, Özlem TEMEL, Feyza YILDIZ, Meral İNALHAN

Akut Kolestatik Hepatit ile Seyreden Bir Epstein-Barr Virus Enfeksiyonu:olgu Sunumu

Epstein-Barr virüs (EB V), akut hepatitin nadir nedenlerinden biridir ve sıklıkla ateş, boğaz ağrısı, adenopati triadı ile karakterize enfeksiyöz mononükleoz nedenidir. Bu hastalıkta karaciğer tutulumu genellikle hafif derecede olup kendiliğinden düzelinağır kolestaz ise nadiren görülür. Bu yazıda karaciğer fonksiyon testleri, alkalen fosfataz, gama glutamil transpeptidaz ve bilirubin düzeylerinde yükseklik bulunan ve akut kolestatik hepatit etkeni olarak EBV saptanan üç yaşında kız hasta sunulmuştur.

Cholestatic hepatitis due to epstein-barr virus infection:A case report

A rare cause ofacute hepatitis is Epstein-Barr virus (EBV) .The main disease caused by EBV is ınfectious mononucleosis characterized by sore throat fever and adenopathy triad. Liver involvement is usually mild and resolves spontaneously severe cholestasis is rare. We report here three-year--oldgirl with cholestatic hepatitis, presenting with elevated liverjunction tests, alkalen phosphatase, gama glutamil transpeptidase and bilirubin.

PDF

___

1 Johannsen EC, Schooley RT, Kaye KM. EpsteinBarr Virus (Infectious mononucleosis). In:Mande/1 GL, Dolin R, Bennett JE, eds. Principles and Practice of Infectious Diseases, 6th ed. Philadelphia: Churchill Livingstone, 2005:1801- 20
2- Arman D. jnfeksiyoz Mononuk/eoz. Topr;u AW, Soyletir G, Doganay M, ed jnfeksiyon Hastahklan ve Mikrobiyolojisi, 2. Baskz. jstanbul: Nobel Tzp Kitabevleri, 2002:696-701
3- Shaw NJ, Evans JH Short reports. Liver failure and Epstein-Barr virus infection. Arch Dis Child 1988; 63:432-445
4- Jenson HB. Epstein-Barr Virus. In: Behrman RE, Kliegman RM, Jenson HB (eds). Textbook of Pediatrics (16th ed). Philadelphia: WB Saunders, 2000:977-981
5- Nancy F. . Epstein-Barr Virus Hepatitis: Case Series and Review. Southern Medical Association 2006; 99:544-47.
6- Hoagland RJ: The transmission of infectious mononucleosis. Am J Med Sci 1995; 3: 229-262
7-Paloheimo JA, Halnonew PI: A case on mononucleosis-like syndrome after blood transfusion from a donor with symptomatic mononucleosis. J Cardiovasc Surg 1965; 6:558 (letter) CiLT: 42 YIL: 2011 SAYI: I
8- Schooley RT: Epstein-Barr Virus (infectious mononucleosis). In: Mandell GL, Benett JE, Dolin R, eds. Principle and practices on infectious diseases, 4th ed. New York 1995: Churchill Livingstone; 1364-1377
9- Zaia JA: Infections in organ transplant recipients. In: Richman DD, Whitley RJ, Hayden FG, eds. Clinical Virology: New York 1997: Churchill Livingstone;87-JJO
10- Finkel M, Parker GW, Fanselau HA. The hepatitis of infectious mononucleosis: experience with 235 cases. Mil Med 1964; 129:533-538
11- Karaman 6, Us/an L c;olbay M, Acarturk G, Yuksel $, Danalzoglu A. Akut hepatitin nadir sebeplerinden biri Epstein-Barr viriis: olgu sunumu. BakzrkOy TzpDergisi 2007; 3:115-7
12-White NJ, Juel-Jensen BE. Infectious mononucleosis hepatitis. Semin Liver Dis 1984; 4:301-306
13- Whitelaw F, Brook MG, Kennedy N, et al. Haemolytic anaemia complicating Epstein-Barr virus infection. Br J Clin Pract 1995; 49:212-213
14- Sainsbury R, Smith PK, LeQuesne G, et al. Gallbladder wall thickening with infectious mononucleosis hepatitis in an immunosuppressed adolescent. J Pediatr Gastroenterol Nutr 1994; 19:123-125
15- Devereaux CE, Bemiller T, Brann 0. Ascites and severe hepatitis complicating Epstein-Barr infection. Am J Gastroenterol1999; 94:236-240 16- Gray JJ, Caldwell J, Silis M The rapid serological diagnosis of infectious mononucleosis. J Infect 1992; 25:39-46
17- Hinedi TB, Koff RS. Cholestatic hepatitis induced by Epstein-Barr virus infection in an adult. Dig Dis Sci 2003; 48:539-541
18- Canovic P, Gajovic 0, Todoro vic Z, Mijailovic Z. Epstein-Barr virus hepatitis associated with icterus-a case report. Med Pregl 2006; 59:179-82
19- Schaade L, Meilecke R, Buttgen S, Ritter K. Manganese superoxide dismutase-inhibiting autoantibodies in cholestatic Epstein-Barr viral hepatitis. Dtsch Med Wochenschr 1998; 123:1478- 82
20- Chalupa P, Kapsar M, Holib M Acute acalculous cholecystitis with pericholecystitis in a patient with Epstein-Barr virus infectious mononucleosis.Med Sci Monit 2009; 15:30-3
21- Yuge A, Kinoshita E, Moriuchi M, et al. Persistent hepatitis associated with chronic active Epstein-Barr virus infection. Pediatr Infect Dis J 2004; 23:74-76
22- Chiba T, Goto S, Yokosuka 0, et al. Fatal chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis. Eur J Gastroenterol Hepatol 2004; 16:225-228