Nazmi YÜKSEK, NURİ ALTUĞ, ABDULLAH KAYA, Tevfik Zahid AĞAOĞLU, Yaşar GÖZ, CUMALİ ÖZKAN

Dose dependent effectiveness of topical selamectin on puppies with ascaridiosis

Bu çalısmada, askaridiozisli yavru köpeklerde selamektin’in farklı dozlarda topikal uygulamasının etkinligi arastırıldı. Çalısma 40-60 günlük yaslarda 12 yavru kopek üzerinde yapıldı. Hayvanlar iki esit gruba bölündü. Birinci grup köpeklere (grup I) 6 mg/kg/CA dozunda, diger gruba (grup II) ise 12 mg/kg/CA dozunda topikal selamektin uygulandı. Askarit yumurtaları Mc Master teknigi ile tedavi öncesi (0. gün) ve tedavi sonrası (7. ve 14. gün) sayıldı. Klinik, hematolojik ve biyokimyasal bulgular 0., 7. ve 14 günlerde incelendi. Tedavi öncesiyle karsılastırıldıgında grup II’deki yavru köpeklerde 14. günde eritrosit sayıları (p

Anahtar Kelimeler:

köpek yavrusu, askaridiozis, ilaç tedavisi, dışkı, iplik solucanı enfeksiyonları, köpek, klinik görünüm, avermektinler, biyokimyasal parametreler

Askaridiozisli yavru köpeklerde topikal selamektin uygulamasının doza bağlı etkinliği

This study evaluated the effects of different doses of Selamectin’s topical application on puppies with ascaridiosis. The study involved 12 puppies up to 40-60 days old. Animals were divided into two equal groups; dogs in the group I were treated with topical selamectin at the dose of 6 mg/kg, body weight (bw), the others (Group II) were treated with topical selamectin at the dose of 12 mg/kg, bw. Ascaride eggs were counted before treatment (day 0) and after treatment on the day 7 and 14 using the Mc Master technique. The clinical, hematological, and biochemical findings of day 0, 7, and 14 were also examined. Total red blood cell (RBC) of puppies in group II (p<0.05) and hematocrite value in both groups significantly increased on the 14th day compared prior to the treatment (p<0.01); leukocyte numbers decreased in the group II on the 7th (p<0.05) and 14th (p<0.01) days compared prior to the treatment. Differential leukocyte count revealed a significant decrease in the proportion of eosinophil after treatment in both groups on the 14th day (p<0.01). Total protein concentrations increased in both groups of treatment regimen on day 7 (p<0.05) and 14 (p<0.01). But, albumin and globulin concentrations increased only in the group II of treatment regimen on day 14 (p<0.05). Egg counts per gram of faeces in both group decreased after treatment but this was more obvious in group II. As a result, it is determined that a considerable improvement was achieved in a shorter time in group treated with 12 mg/kg of selamectin when clinical, haematological, biochemical parameters and egg counts were taken into consideration.

Keywords:

puppies, ascaridiosis, drug therapy, faeces, nematode infections, dogs, clinical aspects, avermectins, biochemical parameters,

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Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi-Cover

ISSN: 1017-8422
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Yüzüncü Yıl Üniv. Veteriner Fak.

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