Özgür EFİLOĞLU, Turgay TURAN, Asıf YILDIRIM, İsmail ULUS, Meftun ÇULPAN, Ramazan Gökhan ATIŞ, Turhan ÇAŞKURLU

Tek merkezin testis tümörü tedavisindeki yaklaşımı ile güncel kılavuzların değerlendirilmesi

Amaç: Testis tümörleri erkeklerdeki malign tümörlerin yaklaşık %1’ini oluşturur. Testis tümörlerinde tedavi başarısının yüksek olması nedeniyle mortalite oranları oldukça düşüktür. Çalışmamızda son 13 yıl içinde kliniğimizde testis tümörü ön tanısıyla radikal orşiektomi yapılan hastaların histopatolojik değerlendirme sonuçları ile uygulanan tedavilerle beraber onkolojik sonuçların ortaya konulması hedeflenmiştir. Gereç ve Yöntemler: Bu çalışmaya 2002- 2015 yılları arasında kliniğimizde testiküler kitle sebebiyle radikal orşiektomi yapılmış 152 hastadan en az 12 aylık takibi olan ve takiplerine düzenli olarak gelen 138 hasta dahil edilmiştir. Hastaların tanı yaşı, kitle boyutları, histopatolojik verileri, uygulanan tedaviler, takip ve sağkalım durumu retrospektif olarak değerlendirildi. Bulgular: Çalışmamızdaki ortalama takip süresi 80,7 ay ( 16 ay - 166 ay ) idi. Malignite saptanan 138 hastanın 73’ ünde (% 52,9) seminomatöz Germ hücreli tümör (GHT), 59’ unda (%42,7) non-seminomatöz GHT ve 3’ ünde (%2,2) seks kord stromal tümör ve 3’ ünde (%2,2) lenfoma saptandı. Takip süresince 17 (%13) hastada nüks gelişirken, 6 hastada (%4,7) hastalığa bağlı ölüm gerçekleşti. Genel onkolojik başarı oranı % 95,7 olarak saptandı. Sonuç: Testis tümörü tedavisinde kılavuz önerileri sürekli güncellenmektedir. Biz de çalışmamızda değişen kılavuz önerilerine göre tedavi protokollerimizi güncelleyerek literatür ile uyumlu onkolojik başarı elde ettik.

Anahtar Kelimeler:

Testis, germ hücreli tümör, germ hücreli olmayan tümör

Current assessment of guidelines by a single-center approach to testicular tumor treatment

Objectives: Testicular tumors make up approximately 1% of male malignant tumors. Because of the high rate of success in testicular tumors, mortality rates are very low. In our study, it is aimed to evaluatehistopathological results of the patients who had radical orchiectomy with prediagnosis of testicular tumor and treatments with oncologic outcomes for about 13 years. Material and Methods: Our study includes 138 patients with at least 12 months follow up on regular basis from 152 patients who had radical orchiectomy due to testicular mass between 2002 and 2015. The age of diagnosis of the patient, mass sizes, histopathological data, treatments, follow up and survival status were assessed retrospectively. Results: The average follow-up period was 80.7 months (16-166 months) in our study. In the analysis of 138 patients, it was seen seminomatous germ cell tumors (GCT) in 73 cases (52.9%), non- seminomatous GCT in 59 cases (42.7%) and sex cord stromal tumors in 3 cases (2.2%) and lymphoma in 3 cases (2.2%). During follow-up, recurrence was observed in 17 (13%) patients, disease-related death was occurred in 6 (4.7%) patients. Overall oncological success rate was 95.7%. Conclusion: Guide recommendations for treatment of testicular tumors are constantly updated. In our study, we also achieved an oncologic success consistent with the literature by updating treatment protocols according to changing guideline recommendations.

Keywords:

Testis, germ cell tumor, nongerm cell tumor,

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