Saç Beyazlama ve Saç Kaybı Skorları ile Erektil Disfonksiyon Arasındaki İlişki

Amaç: Yaşlanma, insanoğlunun engel ola - madığı fizyolojik bir süreçtir ve bu süreç içeri - sinde genellikle 50 yaş sonrası saçlarda dökülme ve beyazlama sık görülmektedir. Son zaman - larda saç beyazlaması ya da dökülmesi ile ok - sidatif stress arasında ilişki olduğunu gösteren çalışmalar mevcuttur. Yine ilerleyen yaşlarda özellikle oksidatif stresin rol aldığı aterosklero- za bağlı erektil disfonksiyonun (ED) da görül - me sıklığının arttığı bilinen bir gerçektir. Bu çalışmada ortak etyolojiyi paylaşan bu iki klinik antiteyi derecelendirmeye yönelik skorlama sis- temleri arasındaki ilişkiyi araştırmak istedik. Gereç ve Yöntemler: Çalışmaya 50 erektil disfonksiyon hastası ve 50 sağlıklı kontrol alındı. Her iki gruptaki hastalarda hipertansiyon, dia - betes mellitus, bel çevresi, kalça çevresi, sigara, peyroni varlığı, koroner arter hastalığı öyküsü, testosteron düzeyleri, LH, FSH, Prolaktin, Açlık kan şekeri ve yine tüm hastalarda İİEF-5 skorla- ması yapıldı. Saç değerlendirilmesinde gri/beyaz saç ölçeği (gray/white hair scale) ve saç kaybı (hair losing) kullanıldı. Bulgular: ED grubundaki hastalarda kont- rol grubuna göre diyabet, hipertansiyon, glukoz, kilo, bel çevresi değerleri anlamlı olarak yüksek çıkmıştır. Yine çalışmamızın ana konusu olan ED grubunda saç beyazlığı ve saç dökülmesi oranlarına bakıldığında da kontrol grubuna göre sonuçlar anlamlı olarak yüksek çıkmıştır. Sonuç: Üroloji polikliniğimize başka bir şikayetle gelen, erken saç beyazlaması yada dö - külmesi olan hastalarda oksidatif stresin neden olabileceği ED’ yi sorgulamamız gerektiğini dü- şünmekteyiz.

Association between Hair Whitening and Hair Loss Scores and Erectile Dysfunction

Aim: Aging is a physiological process that can’t be prevented by human beings, and in this process, hair loss and whitening are often seen after 50 years of age. There have been recent studies showing that there is a relationship between hair whitening or losing and oxidative stress. It is also a known fact that the incidence of erectile dysfunction (ED) due to atherosclerosis, especially oxidative stress, is increasing in later ages. In this study we wanted to investigate the relationship between scoring systems for evaluating these two clinical entities that share a common etiology. Material and Methods: 50 erectile dysfunc- tion patients and 50 healthy controls were in - cluded in the study. Patients in both groups were questioned about the presence of hypertension, diabetes mellitus, Peyronie’s disease and smok- ing status. IEEF-5 scores, weight, waist and hip circumferences, serum levels of testosterone, LH, FSH, prolactin, albumin and fasting blood glucose of all participants were obtained. Gray / white hair scale and hair losing scale were used in hair evaluation. Results: The presence of diabetes, hyperten- sion, coronary artery disease, serum glucose, al- bumin and testosterone levels, weight and waist circumferences were significantly different in ED group compared to the controls. Gray/white hair scale and hair loss scale in the ED group were also significantly different compared to the controls. Conclusion: In our urology polyclinics, in patients with premature hair whitening or los - ing, we need to question about ED which may be caused by oxidative stress, even in patients with other complaits.

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1. Arck PC, Overall R, Spatz K, et al. Towards a “free radical theory of graying”: melanocyte apoptosis in the aging hu - man hair follicle is an indicator of oxidative stress induced tissue damage. Faseb J 2006; 20: 1567-69.
2. Wood JM, Decker H, Hartmann H, et al. Senile hair gra - ying: H202-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair Faseb J 2009; 23: 2065-75.
3. Montorsi P, Montorsi F, Schulman CC. Is erectile dysfunc- tion the ‘tip of the iceberg’ of a systemic vascular disorder? Eur Urol 2003; 44: 352-54.
4. Endemann DH, Schiffrin EL, Endothelial dysfunction. J Am Soc Nephrol 2004; 15: 1983-92.
5. Costa C, Virag R. The endothelial-erectile dysfunction con- nection: an essential update. J Sex Med 2009; 6: 2390-2404. Guay AT. ED2: erectile dysfunction=endothelial dysfuncti- on. Endocrinol Metab Clin N Am 2007 ; 36: 453-63.
6. Miric D, Fabijanic D, Giunio L, et al. Dermatological indi - cators of coronary risk: a case –control study. Int J Cardiol 1998; 67: 251-55.
7. Mansouri P, Mortazavi M, Eslami M, Mazinani M. And - rogenetic alopecia and coronary artery disease in women. Dermatol Online J 2005; 11:2.
8. Kocaman SA,Cetin M, Durakoglugil ME, et al. The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rat- her than chronological age. Anadolu Kardiyol Derg 2012, DOI: 10.5152/akd.2012.150.
9. Erdogan T, Kocaman S.A, Cetin M, et al. Premature Hair Whitening is an Independent Predictor of Carotid Intima- media Thickness in Young and Middle-aged Men. Intern Med 2013;52: 29-36.
10. Amr Abdel Aziz ElFaramawy, Irini Samuel Hanna, Reham Mohamed Darweesh, Ahmed Shehata Ismail, and Hossam Ibrahim Kandil. The degree of hair graying as an indepen - dent risk marker for coronary artery disease, a CT coronary angiography study. Egypt Heart J 2018;70:15–19.
11. Ross R, Glomset J, Harker L. Response to injury and athero- genesis. Am J Pathol 1977;86:675-84.
12. Tobin DJ, Paus R. Graying gerontobiology of the hair follic- le pigmentary unit. Exp Gerontol 2001;36: 29-54.
13. Kauser S, Thody AJ, Schallreuter KU, et al. A fully functio - nal proopiomelanocortin/ melanocortin-1 receptör system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology 2005;146: 532-43.
14. Bacon CG, Hu F B,Feldman HA, et al. Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 2002; 25:1458.
15. Fedele D, Coscelli C, Santeusanio F, et al. Erectile dysfuncti - on in diabetic subjects in Italy. Diabetes Care 1998; 21: 1973.
16. Patel JP, Lee EH, Mena-Hurtado CI, Walker CN. Evaluati- on and management of Erectile Dysfunction in the Hyper - tensive Patient. Cuu Cardiol Rep 2017;19:89.