Hamide Ayben KORKMAZ, Yilmaz APAYDIN, İlkay CEYLAN

Beyin ölümü organ donörlerinde norepinefrin infüzyonunun greft fonksiyonu üzerine etkileri: Retrospektif bir çalışma

Amaç: Beyin ölümü gerçekleşen organ donörlerinde vazoaktif ilaç kullanımının renal alıcı greft fonksiyonu üzerindeki etkisini araştırmak. Yöntemler: Merkezimizde Temmuz 2017 ile Kasım 2021 arasında, beyin ölümü gerçekleşen 30 organ bağışçısından ve 30 alıcıdan alınan klinik veriler geriye dönük olarak analiz edilmiştir. Bulgular: 30 kadavra donörünün hepsinde norepinefrin infüzyonu kullanılmıştı. 11 donörün inotrop ilaç kombinasyonuna sahip olduğu görüldü. Norepinefrin infüzyonlarının ortalama dozu 0.2 mcg/kg/dk idi. Donörlerde norepinefrin süresi ve dozları ile böbrek alıcılarında greft reddi, greft kaybı ve diyaliz gereksinimi arasında ilişki yoktu. Sonuç: Beyin ölümü organ bağışçısında sıvı resüstasyonunun yeterli olduğu durumlarda .0.2 mcg/kg/dk'nın altındaki intravenöz norepinefrin infüzyonunun, renal greft fonksiyonu üzerine etkisi olmadığı görüldü.

Anahtar Kelimeler:

Beyin ölümü, donör, vazoaktif ilaçlar, greft sağkalımı

Norepinephrine infusion in brain dead organ donor: A retrospective study on its effects on graft function after renal transplant

Objective: To investigate the effect of vasoactive drugs use in brain-dead organ donors in renal recipient graft function. Material and Methods: Clinical data from 30 brain-dead organ donors, and 30 recipients in our center were analyzed retrospectively between July 2017 and November 2021. Results: Norepinephrine infusion was used in all 30 cadaveric donors, where 11 donors had inotropic combinations. Norepinephrine was infused at a median dose of 0.2mcg/kg/min. There was no relationship between duration and doses of norepinephrine in donors and graft rejection, graft loss, and dialysis requirement in renal recipients. Conclusion: Intravenous norepinephrine infusion below 0.2mcg/kg/min had no effect on graft function in the renal recipient, where fluid restitution was sufficient in the cadaveric donor.

Keywords:

brain dead, organ donors, vasoactive drugs, graft survival,

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