Eritroblastozis fetalise bağlı blueberry Muffin bulgusu
Blueberry muffin lezyonu yaygın kırmızı-mavi makülopapüler lezyonlarla karakterize bir deri bulgusudur. Sıklıkla jeneralize olur; ancak gövde, baş ve boyunda yerleşme eğilimi vardır. Bluberry muffin lezyonlar dermal eritropoezin bulgusu olup kronik ve şiddetli anemilerle birlikte görülen intrauterin enfeksiyonlar ve hematolojik hastalıklarla beraber görülür. TORCH (toksoplazmozis, rubella, sitomegalovirüs, herpes simpleks) grup enfeksiyonlar, ABO ve Rh uyuşmazlığı gibi yenidoğanın hemolitik hastalığı ve herediter sferositoz blueberry muffin belirtisinin en iyi bilinen nedenleridir. Ayırıcı tanısında konjenital neoplastik hastalıklar ve vasküler lezyonlar yer alır. Bu yazıda, eritroblastozis fetalise bağlı bluberry muffin bulgusu olan bir yenidoğan bebek sunulmuş ve yenidoğanlarda görülen mavi-kırmızı makülopapüler lezyonların ayırıcı tanısında blueberry muffin lezyonların da düşünülmesi gerektiği vurgulanmıştır.
Blueberry Muffin sign due to erythroblastosis fetalis
Blueberry muffin sign is a cutaneous manifestation characterized by widespread reddish-blue maculopapular lesions. The eruptions are often generalized but favor the trunk, head, and neck. Blueberry muffin skin lesions are manifestations of dermal haematopoiesis and are associated with both intra-uterine infections and hematological disorders with chronic and severe anaemia. TORCH (toxoplasmosis, rubella, cytomegalo- virus, herpes simplex) group infections, hemolytic disease of the newborn (ABO and Rh incompatibility) and hereditary spherocytosis are well-known causes for blueberry muffin sign. The differential diagnosis includes congenital neoplastic disorders and vascular lesions. Herein, a case of blueberry muffin sign in a newborn baby due to erythroblastosis fetalis is reported and it has been emphasized that blueberry muffin sign should be taken into consideration in the differential diagnosis of blue-red maculopapular lesions in newborns.
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