The Effect of Bitter Almond Oil on The Some Alterations in Liver Tissue of Experimental Diabetic Rats

Deneysel Diyabetin Sıçan Karaciğer Dokusunda Oluşturduğu Bazı Değişiklikler Üzerine Acı Badem Yağının EtkisiBu çalışma, deneysel diyabet oluşturulan sıçanlarda acı badem yağının karaciğer dokusunda yağ asidi bileşimi, malondialdehit, indirgenmiş glutatyon, total protein, A, D, E ve K vitaminleri, kolesterol ve bazı sterol parametreleri üzerinde etkisinin araştırılması için tasarlandı. Sıçanlar kontrol (K), streptozotosin (STZ) ve streptozotosin+acı badem yağı (STZ+ABY) olmak üzere üç grubu ayrıldı. STZ gruplarına intraperitoneal enjeksiyonla streptozotosin (45 mg/kg) verilerek diyabet oluşturuldu. Acı badem yağı grubundaki sıçanlara haftada iki gün 1ml/kg dozunda intraperitoneal enjeksiyonla acı badem yağı ve ayrıca deney boyunca toz haline getirilmiş 2 gr acı badem çekirdeği, 500 ml içme suyuna eklenerek verildi. Bu uygulamalar 8 hafta boyunca sürdü. Kontrol grubuna göre, STZ grubunun karaciğer dokusunda MDA ve total protein düzeyinin anlamlı bir şekilde (p

Van Veterinary Journal

The present study was designed to evaluate the impact of bitter almond oil on malondialdehyde, reduced glutathione, total protein, fatty acid composition, A, D, E and K vitamins, cholesterol and some sterols parameters in liver tissue of experimental diabetes in rats. The rats were divided into three groups: control (C) streptozotocin (STZ), streptozotocin+bitter almond oil (STZ+BAO) groups. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin (45 mg/kg). 1 ml/kg the dose bitter almond oil was intraperitoneally injected twice in a week to the streptozotocin+bitter almond oil (STZ+BAO), and additionally 2 g/500 ml dose of bitter almond seed powder was added to the drinking water of these rats. The experiment continued for 8 weeks. It was observed that MDA and total protein levels were significantly increased (p

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