Yetişkin Diyabetik Hastalarda HbA1c ve 25-hidroksi D Vitamini Düzeyleri Arasındaki İlişki

Amaç: Bu çalışmanın amacı, bir eğitim ve araştırma hastanesinin dahiliye diyabet ve endokrinoloji polikliniğine başvuran tip II Diabetes Mellituslu hastalarda D vitamini düzeylerini belirlemek ve HbA1c ile 25-hidroksi D vitamini düzeyleri arasındaki ilişkiyi belirlemektir. Materyal ve Metot: Çalışmamızın materyalini hastanemiz dahiliye diyabet ve endokrinoloji polikliniğine başvuran tip II DM hastaları oluşturdu. Çalışmamıza dahil edilen hastaların verileri 2018-2019 yılları arasında hastane bilgi yönetim sisteminden elde edilmiştir. Bulgular: Çalışmaya alınan hastalarda HbA1c ve 25-hidroksi D vitamini düzeyleri belirlendi. HbA1C düzeyleri belirlenen normal değerlerden 9.023 ± 1.72 (%) yüksek bulundu. 25-hidroksi D vitamini düzeyleri 13.94 ± 4.12 ng/ml idi ve normal değerlerden düşüktü. Tip II DM hastalarında HbA1c düzeyleri ve 25-hidroksi vitamin D düzeyleri istatistiksel olarak anlamlı bulundu (p<0.05). 25-hidroksi D vitamini düzeyleri ile HbA1c düzeyleri arasında negatif korelasyon vardı (r=-0,51). Sonuç: Sonuç olarak; bizim çalışmamızda ise HbA1c değerleri ile 25-hidroksi vitamin D düzeyleri arasında orta düzeyde negatif korelasyon saptandı. Tip II DM'li hastalarda HbA1c değerleri yükselirken, 25-hidroksi vitamin D seviyeleri %50 düzeyinde düşmektedir. Tip II DM'li hastaların tedavisini düzenlemek ve hastalığın ilerlemesini azaltmak ve hastalığı kontrol altına almak için glukoz regülasyonu sağlayarak HbA1c değerlerinin normal seviyelere indirilmesi önemlidir.

Anahtar Kelimeler:

Tip II diabetes mellitus, HbA1c, 25-hidroksi D vitamini, Korelasyon

The Relationship Between HbA1c and 25-hidroxy Vitamin D Levels in Adult Diabetic Patients

Objective: The aim of this study was to determine vitamin D levels in patients with type II Diabetes Mellitus who applied to the internal medicine diabetes and endocrinology policlinic of a training and research hospital, and to determine the relationship between HbA1c and 25-hydroxy vitamin D levels. Material and Method: Type II Diabetes Mellitus patients constituted the material of the study. The study was conducted between 2018-2019. The data were obtained from the hospital information management system. Those with bone-derived malignancies and pregnant women were excluded from the study. A total of 65 patients, 40 (61%) female and 25 (39%) males were included in the study. Statistical analyzes were made with the help of IBM SPSS for Windows 26.0 package program. The normal distribution was tested for the categories of factors affecting vitamin D levels. Accordingly, the hypothesis test was chosen and the descriptive statistics values suitable for the used hypothesis test were calculated. Variables indicated by measurement mean ± SD, smallest and largest; Variables that are represented by numbers are indicated by %. Pearson correlation coefficients were used to evaluate the correlations. Results: HbA1c and 25-hydroxy vitamin D levels were determined in the patients included in the study. HbA1C levels were found to be 9,023 ± 1.72 (%) higher than the normal values. 25-hydroxy vitamin D levels were 13.94±4.12 ng/ml and were lower than normal values. HbA1c levels and 25-hydroxy vitamin D levels were found to be statistically significant in type II Diabetes Mellitus patients (p<0.05). A negative correlation was calculated between 25-hydroxy vitamin D levels and HbA1c levels (r=-0.51). Conclusion: As a result, HbA1c values were found to be high as expected in patients with Type II Diabetes Mellitus. On the other hand, 25-hydroxy vitamin D levels were found to be low. In these patients, low 25-hydroxy vitamin D makes vitamin supplementation important. However, the permanent inclusion of 25-hydroxy vitamin D in treatment protocols necessitates further research.

Keywords:

Correlation, HbA1c, Type II Diabetes Mellitus, Vitamin D,

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