Müzeyyen ASLANER AK, İlknur ÇEKİM, Şehmus ERTOP

Non-Hodgkin Lenfoma Olgularının Geriye Dönük Değerlendirilmesi: Tek Merkez Deneyimi

AAmaç: Çalışmamızda Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Hematoloji Kliniğinde takip edilen 151 Non- Hodgkin lenfoma tanılı hastanın demografik verileri, tedavi yanıtları ile sağkalım analizlerinin yapılması amaçlandı. Materyal ve Metod: Non- Hodgkin lenfoma tanısı ile izlenen 151 olgunun verileri geriye dönük olarak değerlendirildi. Bulgular: Çalışmaya 151 hasta (81 kadın,70 erkek) dahil edildi. Ortanca yaş 62.6±12.9 olarak saptandı. Hastaların tanılarına bakıldığında 83(%55) hastanın diffüz büyük B hücreli lenfoma, 21(%13.9) hastanın marjinal zon lenfoma, 10(%6.6) hastanın foliküler lenfoma 26 (%17.2) hastanın mantle cell lenfoma, 9(%6.0) hastanın T hücreli lenfoma, 2(%1.3) hastanın diğer lenfoma tanısı aldığı görüldü. Hastaların 64’si tanesi ölmüş, 87 tanesi ise yaşıyor olarak saptandı. Tüm non-hodgkin lenfoma hastalarında ortalama sağ kalım süresi 64 ay iken hastalıksız sağ kalım süresi 63 ay saptandı. Sonuç: Çalışmamızda 5 yıllık sağkalım oranı literatüre göre düşük saptandı. Bunun sebebi hasta popülasyonumuzun büyük çoğunluğunun 65 yaş üstü olması, ileri evre hastalık ve komorbidite oranının yüksek olmasına bağlı olduğunu düşünüyoruz.

Anahtar Kelimeler:

Non hodgkin lenfoma, Genel sağkalım, Hastalıksız sağkalım

Retrospective Analysis of Non-Hodgkin Lymphoma Patients: A Single Institution Experience

Objective: Demografic features, respond the treatment of 151 Non-Hodgkin lymphoma (NHL) patients observed at depertman of hematology,Zonguldak Bülent Ecevit University faculty of medicine in our study. Material and Method: Data of 151 NHL patients were evaluated retrospectively. Results: 151 patients (81 female, 70 male) were included in the study. The median age was 62.6±12.9 years. The diagnoses of the patients were as follows: 83(55%) patients had diffuse large B-cell lymphoma, 21 (13.9%) patients had marginal zone lymphoma, 10(6.6%) patients had follicular lymphoma, 26(17.2%) patients had mantle cell lymphoma, 9(6.0%) patients had T cell lymphoma, and the remaining 2(1.3%) patients had other types of lymphoma. 64 patients died, and 87 of them lived. The mean survival time for all NHL patients was 64 months, while the disease-free survival time was 63 months. Conclusion: In our study, the 5-year survival rate was found to be lower than the literature. We think that this is due to the fact that the majority of our patient population is over 65 years old and the rate of advanced disease and comorbidity is high.

Keywords:

Non-hodgkin lymphoma, Overall survival, Disease-free survival,

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